[Impaired oxidative metabolism in acute inflammatory diseases].

The specific features of lipid peroxidation (LPO) and the activity of enzymatic antioxidants in the plasma and red blood cells of patients with acute appendicitis, phlegmons, and abscesses located in the soft tissues of the shin, hip, buttocks, shoulder, and forearm were comprehensively evaluated. In these diseases, the signs of evolving oxidative stress were revealed irrespective of the site of an acute inflammatory focus. Excess accumulation of LPO products was recorded with the inhibition of antioxidative defense components, including erythrocytic glutathione-dependent enzymes.

[Platelet membrane pathology in vascular complications of type 1 diabetes mellitus].

The purpose of the present study was to define a role of the impaired structural and functional organization of the platelet membrane in the mechanisms of development and progression of vascular complications of type 1 diabetes mellitus (DM). Seventy-seven type 1 DM patients (34 males and 23 females) with different stages of diabetic retinopathy and nephropathy, whose age was 18 to 55 years, were examined. Tlie patients with type 1 DM were found to have pronounced membranous structural and functional changes in the platelets (the increased microviscosity of a lipid phase, the inhibited activity of Na+,K+-ATPase), whose degree correlates with that of vascular complications.