Enhanced In Vitro and In Vivo Autophagy Suppression via LC3 siRNA-Loaded "Smart" Nanoparticles and Doxorubicin Combination Therapy in Triple Negative Breast Cancer.

Autophagy plays a complex role in cancer progression, serving as both a tumor suppressor and a promoter, depending on the context. In triple-negative breast cancer (TNBC), a particularly aggressive subtype with limited therapeutic options, autophagy inhibition has emerged as a promising strategy to enhance the efficacy of chemotherapy. This study investigates the synergistic effects of autophagy suppression using LC3 siRNA-loaded "smart" nanoparticles (LC3siRNA-NPs) in combination with doxorubicin (DOX) to overcome chemoresistance in TNBC.

Therapeutic Effects of Esomeprazole on Pancreatic and Lung Injury in Acute Pancreatitis: An Experimental Study.

: During acute pancreatitis, leakage of pancreatic enzymes into the gland results in autolysis of the pancreas. The lungs are also involved in this process. This study aimed to investigate the therapeutic effects of esomeprazole on damaged pancreatic tissue and affected lung tissue in rats with acute pancreatitis.

Sleep quality, anxiety, and depression in palliative care patients.

Objectives: Sleep problems are common in palliative care patients. In addition, psychological problems can affect sleep quality. The aim of this study was to investigate sleep quality, anxiety, and depression in palliative care patients.

Predicting recurrence in primary spontaneous pneumothorax: The role of the Haller index in emergency department patients.

Background: Primary spontaneous pneumothorax (PSP) is a common condition encountered in emergency departments, typically affecting young, otherwise healthy individuals. Identifying patients at risk for recurrence is critical for optimizing management strategies and preventing complications. This study aimed to evaluate the predictive value of the Haller index in determining the risk of recurrence in patients diagnosed with PSP.

Asthma patients with obesity have a unique phenotype: a subanalysis of the Turkish adult asthma registry.

Objective: The obese-asthma phenotype has gradually increased in the last few years. We aimed to assess the differences between obese and non-obese patients with asthma.

Methods: This research is a subanalysis of the Turkish Adult Asthma Registry (TAAR).