Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation.

HLA "matched" unrelated donor bone marrow transplants are associated with an increased incidence and severity of graft-versus-host disease in comparison with HLA-identical sibling transplants. This is presumably due to HLA and non-HLA histocompatibility differences between donor and recipient. Using a limiting dilution assay, we have previously demonstrated a relationship between cytotoxic T lymphocyte precursor frequency and HLA disparity.

[The action of azepoxole on central alpha 2-adrenoreceptors].

The effect of adrenomimetics on the central alpha 2-adrenoreceptors responsible for mydriasis was studied. It was found that alpha 2-adrenomimetic azepoxole (BHT-933) exerts no effect on the central alpha 2-adrenoreceptors providing mydriasis.