[Significance of determination of lipid-oxidizing catalytic antibodies in patients with ischemic heart diseases].

From the previously examined patients with ischemic heart disease (IHD), the authors formed two groups in whom an original method was used to detect the abnormal lipid-oxidizing anti-Chlamydia antibodies abzymes that increased the serum concentration of malondialdehyde. The effects of the statin rosuvastatin and the antioxidant licopin on abzymes were comparatively studied. Despite the positive impact of therapy with rosuvastatin on lipid metabolism of IHD patients, the agent exerted no effect on the rate of lipid peroxidation and the activity of lipid-oxidizing antibodies.

[Effect of therapy with antibiotics on lipid metabolism and antioxidant reserve of patients with ischemic heart disease during Chlamydia pneumoniae infection].

Effect of therapy with azithromycin and doxycycline on lipid metabolism, processes of lipid peroxidation and state of antioxidant defense was studied in patients with ischemic heart disease with elevated titer of antibodies to Chlamydia Pneumonia. Therapy with azithromycin (500 mg/day for 2 months) was associated with lowering of antibody titer, moderate improvement of lipid spectrum, marked decrease of activity of lipid peroxidation and augmentation of blood plasma antioxidant reserve. There were no such changes in a group of doxycycline treated patients.

[The effect of molecular oxygen and calcium ions on the membrane permeability of erythrocytes].

Extracellular Ca has shown the highest membrane destroying effect of all the factors studied. Its injurious action augmented when blood samples were exposed to atmospheric oxygen. To improve the diagnostic value of biochemical studies at the expense of red cell membrane stabilization the authors recommend the use of blood citrate plasma as the basic object of enzymic studies.

[A study of the enzymes in citrated blood plasma].

Elevated blood serum, vs. the plasma, levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase activities are explained by these enzymes discharge from red cells into the liquid fraction of the blood during its in vitro coagulation. To eliminate the "tube" hemolysis, the authors recommend measurements of these enzymes activities in the blood citrate plasma.