[Influence of high concentration of antibodies to NGF during early embryogenesis on formation of mice behavior in postnatal period].

In this work the influence of high concentration of antibodies to NGF on mouse's progeny has been investigated. During immunization with NGF the highest concentrations of antibodies were created in the first and third days of pregnancy (in different groups of animals). The dependence of abnormalities of mice postnatal development on level of antibodies to NGF at different stages of early embryogenesis has been established.

[The course of the diabetes type I in pregnants with different levels of antibodies to insulin].

The course of the diabetes type I at pregnants (n=120) with different levels of idiotypic (ABI) and antiidiotypic (AB2) antibodies to insulin was investigated. It is known that AB2 to insulin can interact with insulin receptor. It was shown that changes of levels AB1 and AB2 to insulin are often observed at pregnants suffered from diabetes type I.

[Immunomodulators in the "gold standard" of the chronic viral hepatitis C therapy].

The best therapeutic effect in the treatment of patients with chronic virus hepatitis C was observed with the use of cycloferon included into the standard antiviral therapy with alpha-interferon and ribavirine. The 18-month observation revealed an increase of the biochemical and antiviral responses to 41.0 and 30.

[Plasma levels of cytokines in patients with active infiltrative pulmonary tuberculosis].

The levels of interferon-y (IFN-gamma), tumor necrosis factor-gamma (TNF-alpha), and interleukin-8 (IL-8) and their changes during chemotherapy and laser chemotherapy were studied in 97 patients with active infiltrative pulmonary tuberculosis, by taking into account Mycobacterium tuberculosis (MBT) sensitivity to chemical agents. The studies have indicated that the levels of IFN-gamma, TNF-alpha, and IL-8 are increased and may be markers of an active process. Chemotherapy causes a reduction in increased cytokinemia.

[Subtilisin Carlsberg in complex with sodium dodecyl sulfate--an effective catalyst for the solid phase segment coupling of peptides on polyvinyl alcohol cryogel].

Subtilisin Carlsberg (SK) was shown to catalyze the solid phase segment coupling of peptides in complex with sodium dodecyl sulfate (SDS) in an organic medium on Aminosilochrom and polyvinyl alcohol (PVA) cryogel activated with glutaraldehyde or divinylsulfone. Diamines of different lengths with a general formula NH2-(CH2)n-NH2 (n = 2, 4, and 6) were used as spacers between the PVA cryogel and the peptide. A model reaction of enzymatic attachment of the Dnp-Ala-Ala-Leu-OMe tripeptide to the PVA cryogel was carried out by treatment with the SDS-SK complex in a mixture of anhydrous ethanol and DMSO (7: 3, v/v) using a tenfold excess of the carboxyl component.