Publications by authors named "O Lorenzo"
Article Synopsis
- The study investigates the connection between inflammatory biomarkers and cardiovascular events in type 2 diabetes patients with stable coronary artery disease (CAD).
- A total of 964 patients were analyzed, measuring inflammatory markers such as TNF-R1, GDF-15, and hsCRP, to see how these relate to acute ischemic events over a follow-up period of about 5.4 years.
- Results showed that diabetic patients had higher inflammatory marker levels and a greater incidence of cardiovascular events, with TNF-R1 identified as an independent risk factor for these events specifically in diabetic patients.
Objective: To compare the 1-hour postload glucose (1h-PG) value of an oral glucose tolerance test (OGTT) with the metabolic syndrome (MetS) and the Finish Diabetes Risk Score (FINDRISC) in patients with impaired fasting glucose (IFG) to predict type 2 diabetes mellitus (T2DM).
Methods: A cohort study was conducted in patients at a general hospital in Lima, Perú. An OGTT was performed in subjects with IFG who were followed-up for 7 years for T2DM development.
Higher neighborhood disadvantage is associated with weaker interactions among cardiometabolic drivers.
Int J Cardiol Cardiovasc Risk Prev
December 2024
Background: Adiposity, dysglycemia, and hypertension are metabolic drivers that have causal interactions with each other. However, the effect of neighborhood-level disadvantage on the intensity of interactions among these metabolic drivers has not been studied. The objective of this study is to determine whether the strength of the interplay between these drivers is affected by neighborhood-level disadvantage.
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- ATTR-CM is increasingly common, and the medication diflunisal has been shown to stabilize certain markers related to heart function, but its effects on heart structure changes over time need further research.
- The AMILCA-DIFLU study involved 12 ATTR-CM patients, with only nine completing the year-long treatment, and found that diflunisal did not significantly improve heart disease status, although there was a slight trend toward stabilization in some heart-related measurements.
- Despite showing some potentially positive trends, diflunisal was well tolerated overall, with only a minor increase in renal dysfunction that didn’t lead to any serious complications or the need to stop treatment.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are global health burdens with rising prevalence. Their bidirectional relationship with cardiovascular dysfunction, manifesting as cardio-renal syndromes (CRS) types 3 and 4, underscores the interconnectedness and interdependence of these vital organ systems. Both the kidney and the heart are critically reliant on mitochondrial function.
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