Publications by authors named "O Loreal"
Background: Previous data in humans suggest that extreme physical inactivity (EPI) affects iron metabolism differently between sexes. Our objective was to deepen the underlying mechanisms by studying rats of both sexes exposed to hindlimb unloading (HU), the reference experimental model mimicking EPI.
Methods: Eight-week-old male and female Wistar rats were assigned to control (CTL) or hindlimb unloading (HU) conditions (n = 12/group).
Iron is essential for cell respiration, muscle metabolism, and oxygen transport. Recent research has shown that simulated microgravity rapidly affects iron metabolism in men. However, its impact on women remains unclear.
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- Intensive use of pesticides leads to environmental contamination and significant health risks due to exposure to chemical residues, particularly affecting the liver, which is crucial for metabolizing these substances.
- A study on a mixture of seven common pesticides revealed strong cytotoxic effects on liver cells, primarily caused by manganese-containing dithiocarbamates (maneb and mancozeb), even at low concentrations.
- The mechanism of toxicity involves oxidative stress and intrinsic apoptosis triggered by altered manganese and zinc levels due to the metabolization of these pesticides, with potential protective effects from zinc supplementation.
Unlabelled: Iron overload is one of the secondary osteoporosis etiologies. Cellular and molecular mechanisms involved in iron-related osteoporosis are not fully understood.
Aim: The aim of the study was to investigate the respective roles of iron excess and hepcidin, the systemic iron regulator, in the development of iron-related osteoporosis.