Publications by authors named "O Leonova"
N-glycome analysis of individual proteins and tissues is crucial for fundamental and applied biomedical research and medical diagnosis and plays an important role in the evaluation of the quality of biopharmaceutical and biotechnological products. The interest in this research area continues to grow annually, thereby increasing the demand for the high-throughput profiling of human blood plasma N-glycome. In response to this need, we have developed an optimized, simple, and rapid protocol for the N-glycome profiling of human plasma proteins.
View Article and Find Full Text PDFBackground: In the twentieth century, the textbook idea of packaging genomic material in the cell nucleus and metaphase chromosomes was the presence of a hierarchy of structural levels of chromatin organization: nucleosomes - nucleosomal fibrils -30 nm fibrils - chromomeres - chromonemata - mitotic chromosomes. Chromomeres were observed in partially decondensed chromosomes and interphase chromatin as ~100 nm globular structures. They were thought to consist of loops of chromatin fibres attached at their bases to a central protein core.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore the relationship between Modic changes (MC) in the spine and MRI findings, as well as symptoms in patients with cervical degenerative disc disease (DDD).
- It involved a retrospective analysis of 121 patients who underwent cervical surgery, comparing preoperative MRI and clinical data, revealing that patients with MC experienced more severe neck pain.
- The findings indicated that MC type 2 is linked to several factors, including disc degeneration and endplate defects, with specific thresholds established for predicting these changes at certain cervical levels.
Proteasomes are multi-subunit protein complexes responsible for protein degradation in cells. Immunoproteasomes and intermediate proteasomes (together non-constitutive proteasomes) are specific forms of proteasomes frequently associated with immune response, antigen presentation, inflammation and stress. Expression of non-constitutive proteasome subunits has a prognostic value in several types of cancer.
View Article and Find Full Text PDFObjective: To examine cognitive intraindividual variability (IIV) dispersion as a predictor of everyday functioning and mortality in persons who are homeless or precariously housed.
Method: Participants were 407 community-dwelling adults, followed for up to 13 years. Neurocognition was assessed at baseline and IIV dispersion was derived using a battery of standardized tests.