Idiopathic facial aseptic granuloma in children: Management and long-term follow-up.

Aims: The primary objective was to study long-term outcomes in children with idiopathic facial aseptic granuloma (IFAG). The secondary objectives were to describe the clinical polymorphism of this entity, the different therapeutic options, and the occurrence of rosacea in this population.

Methods: We selected patients with a clinical diagnosis of IFAG seen in two different hospitals in Normandy between March 2016 and February 2021, and we collected clinical and therapeutic data from computerized medical records.

[A case of "juvenile" self-healing cutaneous mucinosis in an adult].

Introduction: Self-healing juvenile cutaneous mucinosis (SHJCM) is a stereotypical disease in children characterized by the acute onset of subcutaneous papules and nodules on the face, dorsum of the hands and peri-articular regions that disappear spontaneously within a few months or years. A few cases have been reported in adults, but these display more heterogeneous clinical and histopathological features. Herein we report a case with a juvenile clinical presentation in an adult woman.

[Extensive connective tissue nevus in children].

Background: Connective tissue nevus (CTN) is a rare condition of the extracellular matrix components that generally presents as papulae of normal skin colour. This condition may be syndromic or sporadic.

Patients And Methods: We report herein two isolated cases of extensive and infiltrative CTN in children at risk for subsequent joint stiffening.

[Optimization of the purification of human plasma fibronectin by double affinity chromatography using gelatin and heparin Trisacryl LS].

The authors described an optimized method of preparation to obtain pure human plasma fibronectin. The new performances related to the chromatographic and concentration steps, where the saving of time is about 40% and the lyophilization step where the saving of energy is also about 40%. The final product is without any less of either physical and biological activities.