Publications by authors named "O L Warren"
Adipose-derived stem cells (ADSCs) have an important role in the modulation of burned tissue repair through the release of paracrine factors that stimulate the wound healing response. In this study, we tested the hypothesis that smoking status alters the profile of paracrine factors secreted from ADSCs isolated from damaged adipose tissue. Adipose tissue was collected from adult patients (N=8) with severe burn injuries (>20% total body surface area) at the index operation.
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- The study investigated the impact of cardiopulmonary resuscitation (CPR) on brain and skin oxygen levels in pigs experiencing severe hemorrhagic shock, a condition where blood pressure drops critically.
- Using a controlled experiment with 12 swine, results indicated that while CPR increased systolic blood pressure, it did not improve overall tissue oxygenation and, in fact, reduced skin perfusion significantly.
- The findings support previous research suggesting that CPR may not benefit organ oxygenation during hemorrhagic shock and could even have harmful effects.
Introduction: Adipose-derived stem cells (ASCs) are multipotent stem cells capable of differentiating into many cell lineages. They play an important role in wound healing by secreting cytokines. Prior studies have demonstrated the presence of proinflammatory cytokines in burn wounds.
View Article and Find Full Text PDFPurpose: This work aimed to investigate the validity of wearable activity monitors (WAMs) as an objective tool to measure the return toward normal functional mobility following abdominal wall surgery. This was achieved by quantifying and comparing pre- and postoperative physical activity (PA).
Methods: A multicenter, prospective, observational cohort study was designed.
A retrospective cohort study of patients undergoing laparoscopic inguinal hernia repair compared short- and long-term outcomes between individuals with or without history of previous abdominopelvic surgery, aiming to determine the feasibility of totally extraperitoneal (TEP) repair within this population. All patients who underwent elective TEP inguinal hernia repair by one consultant surgeon across three London hospitals from January 2017 to May 2023 were retrospectively analysed to assess perioperative outcomes. Two hundred sixty-two patients were identified, of whom two hundred forty-three (93%) underwent laparoscopic TEP repair.
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