Publications by authors named "O L Kon"
Article Synopsis
- This study is the first of its kind to statistically assess how well the Collaborative Ocular Tuberculosis Study (COTS) calculator predicts the need for antitubercular therapy (ATT) in patients with suspected tubercular uveitis (TBU) in an international setting.
- The main goal was to determine if a score of 4 or higher on the COTS calculator effectively guides the initiation of ATT.
- Results showed that among 492 participants, 45.7% received a high probability for ATT initiation, and the COTS-5 score showed the highest specificity at 88.7%, suggesting its effectiveness compared to clinician judgment.
Drug-resistant tuberculosis treatments, the case for a phase III platform trial.
Bull World Health Organ
September 2024
Most phase III trials in drug-resistant tuberculosis have either been underpowered to quantify differences in microbiological endpoints or have taken up to a decade to complete. Composite primary endpoints, dominated by differences in treatment discontinuation and regimen changes, may mask important differences in treatment failure and relapse. Although new regimens for drug-resistant tuberculosis appear very effective, resistance to new drugs is emerging rapidly.
View Article and Find Full Text PDFBackground: A post-authorisation safety study (PASS) on delamanid (DLM) was conducted as part of a post-approval commitment to the European Medicines Agency. The aim of this study was to evaluate the use of DLM in a real-life setting, its safety, and treatment outcomes in patients with multidrug-resistant TB (MDR-TB).
Methods: This was a prospective, multicentric, non-interventional study conducted in the European Union.
Introduction: The role of Xpert Ultra in bronchoalveolar lavage (BAL) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples for pulmonary and mediastinal lymph node tuberculosis (TB) remains unclear.
Methods: This was a retrospective observational service evaluation at a tertiary TB centre in a low-incidence setting. The diagnostic indices of Xpert Ultra, smear and culture (with cytology for EBUS-TBNA samples) were compared with culture positivity or a composite reference standard of clinical TB diagnosis.