Publications by authors named "O L Balabanova"

Article Synopsis
  • - The study aimed to create a method for identifying mebeverine and its metabolites in urine and hair to avoid false positives for psychoactive substances when using immunochromatographic tests.
  • - Researchers utilized mebeverine tablets and enzymes to extract metabolites, analyzing them using advanced chromatographic techniques after administering the drug to guinea pigs and collecting urine and hair samples.
  • - The findings revealed that mebeverine and its metabolites were present in urine, while hair analysis indicated only the presence of the native mebeverine molecule, suggesting that hair tests can differentiate between therapeutic use of mebeverine and the use of psychoactive drugs.
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Objective: To develop the method of biological fluids' sample processing and mebeverine detection to exclude false results' receiving when diagnosing drug intoxication.

Material And Methods: The study was carried out using «Mebeverine» (NJCO «North star», Russia) medicine and hydrolysis by enzymes, namely papain, chymotrypsin, trypsin, chymopsin and hyaluronidase, was applied for sample processing. The extractions were analyzed by methods of HPLC-MS/MS on Nexera XR modular liquid chromatograph with LCMS-8050 (Shimadzu) tandem mass spectrometer and GC-MS on gas chromatograph connected with QP-2020 (Shimadzu, Japanese) mono quadrupole mass spectrometer.

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Therapeutic-diagnostic videothoracoscopy was used in complex treatment of hemothorax in 86 patients for isolated and combined stab-slash wounds and closed traumas of the chest. Thoracoscopy was not used in 321 patients with the same pathology taken as control. It was found that videothoracoscopy used for medium and big hemothorax always allowed the doctors to make the precise topical diagnosis of chest injury and due to medicinal endosurgical manipulations the thoracotomies were made 2.

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The authors describe specific features of the diagnosis and emergency medical care at the prehospital period developed on the basis of treatment of more than 5000 patients with isolated and combined injuries of the chest and abdomen. The importance of using the resuscitation-surgical teams, the syndrome diagnostics and stabilization of vital functions at the place of the accident is stressed as well as admittance of the casualties as quickly as possible to an up-to-date specialized multitype traumatology center.

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