Publications by authors named "O Kwiatek"
Peste des petits ruminants virus (PPRV) causes a highly infectious disease affecting mainly goats and sheep in large parts of Africa, Asia, and the Middle East and has an important impact on the global economy and food security. Full genome sequencing of PPRV strains has proved to be critical to increasing our understanding of PPR epidemiology and to inform the ongoing global efforts for its eradication. However, the number of full PPRV genomes published is still limited and with a heavy bias towards recent samples and genetic Lineage IV (LIV), which is only one of the four existing PPRV lineages.
View Article and Find Full Text PDFArticle Synopsis
- Peste des petits ruminants (PPR) is a viral disease affecting mainly sheep and goats, but can also infect other animals like buffalos and camels, highlighting concerns about how the virus spreads between wildlife and livestock.
- Validated serological tools, such as the virus neutralisation test (VNT) and enzyme-linked immunosorbent assay (ELISA), have been used to detect previous infections but their effectiveness for atypical species is still uncertain.
- A study analyzing 793 serum samples found that while VNT and ELISAs showed a high agreement (75-88%) for typical species, the accuracy dropped significantly (44-62%) for atypical species, indicating a need for better diagnostic approaches in these cases.
Article Synopsis
- The production of peste des petits ruminants (PPR) vaccines in Russia relies on two virus strains, "45G37/35-k" and "ARRIAH," which are of common origin.
- A full genome analysis of the PPRV/45G37/35-k strain revealed it is related to the established vaccine strain Nigeria/75/1, but with 248 nucleotide differences, suggesting it is a distinct, unrecognized strain.
- The safety and effectiveness of the Russian vaccine strains need to be thoroughly documented and submitted to the World Organization for Animal Health (WOAH) before they can be distributed widely.
Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries.
View Article and Find Full Text PDFArticle Synopsis
- Peste des petits ruminants (PPR) is a contagious viral disease affecting mainly goats and sheep in Asia, Africa, and the Middle East, caused by the PPR virus (PPRV) with four genetic lineages.
- A study conducted on 429 small ruminants in Nigeria from 2017-2020 found 90 samples from lineage IV and one from lineage II, showing significant genetic diversity.
- The phylogenetic analysis revealed at least four sub-clusters of lineage IV, indicating widespread circulation of various PPRV strains in Nigeria and neighboring countries, making disease control challenging in the region.