ESTRADIOL BLOOD LEVEL AND ESR1 GENE POLYMORPHISM IN WOMEN WITH PREMENSTRUAL SYNDROME.

Objective: The aim: To evaluate the association between estrogen receptor (ESR1) α- Xbal polymorphism with estradiol serum blood level in the patients with premenstrual syndrome.

Patients And Methods: Materials and methods: 50 women with premenstrual syndrome and 20 controls were examined. The level of estradiol was measured in the blood serum in both phases of the menstrual cycle by ELISA method.

Assessment of estrogen receptor gene polymorphism (t-397c variant) in patients with premenstrual syndrome.

Objective: The aim:of the study is to determine the frequency of polymorphism of estrogen receptor gene ESR1 (T-397C variant) in patients with premenstrual syndrome.

Patients And Methods: Materials and methods: 50 women with diagnosis of premenstrual syndrome (the basic group) and 25 persons without it (the control group) were examined. Polymerase chain reaction was used to study T-397C polymorphism of estrogen receptor gene ESR1.

[Coronary score and risk indicators].

Using the method of multi-dimensional statistical analysis in the evaluation of relations between the coronary score and risk factors in 120 men with ischaemic heart disease type stable angine, and in 30 men in a control group the authors revealed: age is a significant negative discriminator of the presence and indicator of the severity of atherosclerotic narrowing of the coronary arteries, cholesterol is a statistically significant positive independent discriminator of the presence and indicator of the severity of atherosclerotic narrowing of the coronary arteries, HDL-cholesterol is a significant negative independent indicator of the severity of the atherosclerotic narrowing of the coronary arteries, triacylglycerols are a positive indicator of the severity of the atherosclerotic narrowing of the coronary arteries only at the borderline of statistical significance, Broca's index of relative body weight is a positive discriminator of atherosclerotic narrowing of the coronary arteries only at the borderline of significance, there is a statistically significant positive additive relationship of quantitative risk factors with the atherosclerotic narrowing of coronary arteries, physical activity is a significant positive discriminator of the presence of atherosclerotic narrowing of the coronary arteries, the oral glucose tolerance test is a positive discriminator of the presence of the atherosclerotic narrowing of the coronary arteries.

[Atherogenicity indices and coronary risk].

The authors compared three different indices, of atherogenicity in 120 men with ischaemic heart disease, type stable angina pectoris (mean age 35.9 +/- 7.54 years) with 30 men of a control group--mean age 42.

[Relative mass and serum lipids in men with various coronary scores].

The authors evaluated the relationship between relative body weight according to Broca and serum lipids in 120 men with stable angina pectoris with a positive coronary score and in 30 men with cardiovertebrogenic syndrome and a negative coronary score. The differences between the Broca index and serum lipid values between men with angina and men of the control group were statistically significant (p less than 0.001); the differences were independent on the value of Broca's index.