Publications by authors named "O Kulkarni"
Regulation of the blood-brain barrier function by peripheral cues in health and disease.
Metab Brain Dis
December 2024
The blood-brain barrier (BBB) is formed by microvascular endothelial cells which are ensembled with pericytes, astrocytes, microglia and neurons in the neurovascular unit (NVU) that is crucial for neuronal function. Given that the NVU and the BBB are highly dynamic and regulated structures, their integrity is continuously challenged by intrinsic and extrinsic factors. Herein, factors from peripheral organs such as gonadal and adrenal hormones may influence vascular function also in CNS endothelial cells in a sex- and age-dependent manner.
View Article and Find Full Text PDFContemporary research evidence has corroborated a gradual loss of central cholinergic neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive dysfunction and impaired motor activity, culminating in the brain cell's death in the disease. The approved drugs for AD treatment can only offer relief from symptoms without addressing the underlying pathological hallmarks of the disease.
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- A 45-year-old man had a scrotal lesion that he had for 25 years and was asymptomatic.
- The lesion was identified as steatocystoma based on its appearance, measuring 20 cm × 10 cm × 8 cm before removal.
- After surgical excision, the pathological examination showed cysts with characteristics similar to hair root sheath epithelium, containing keratin and some calcification.
Article Synopsis
- Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to significant cognitive decline and motor dysfunction due to the loss of cholinergic neurons, with current medications only providing temporary relief of symptoms.
- Novel compounds based on rivastigmine (such as 3q and 6e) were developed and shown to effectively inhibit key enzymes involved in AD, exhibit antioxidant properties, and prevent the aggregation of tau and Aβ proteins.
- These compounds also reduced inflammation in brain cells and restored memory function in animal models, showing increased expression of neuroprotection markers, indicating their potential for treating AD more effectively than existing medications.
The normal ability to distinguish two points from one is known as the two-point discriminative (2PD) sense. This forms an extremely important assessment in patient with injuries to the nerves distributed to the upper extremity. The aim of this study was to estimate the normal reference values of static 2PD in healthy adults and children.
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