Publications by authors named "O Kryukova"
We suggest a new method for the detection of paroxysmal atrial fibrillation by analyzing surface-enhanced Raman scattering (SERS) spectra of blood serum of patients in question in comparison with SERS spectra of the serum of healthy donors. Spectral measurements were carried out on compact SERS substrates in dried blood serum droplets with immediate subsequent processing. To process the spectra, machine learning methods were used, in particular, the logistic regression method and the principal component method.
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- Recent analysis identified over 400 damaging missense ACE mutations, suggesting that carriers of heterozygous loss-of-function ACE mutations may be at risk for late-onset Alzheimer's disease (AD).
- A study measuring blood ACE levels in 41 subjects with different heterozygous mutations revealed that certain mutations (Y215C and G325R) significantly reduced ACE levels, while the R1250Q mutation did not impact ACE levels.
- The findings indicate that measuring blood ACE levels in patients with ACE mutations could help identify those at increased risk for AD, potentially guiding future preventive treatments involving chaperones and proteasome inhibitors to improve ACE function.
Article Synopsis
- Researchers hypothesized that individuals with damaging mutations of the Angiotensin-I-Converting Enzyme (ACE) and low ACE levels may be at risk for late-onset Alzheimer’s disease (AD).
- The study analyzed blood ACE levels in 15 patients with various mutations and confirmed that a common mutation (Y215C) is linked to reduced ACE levels and AD risk.
- Additional mutations were identified that also correlated with decreased ACE levels, suggesting potential risk factors for AD; the research indicates that identifying these mutations may help target individuals who could benefit from specific therapeutic treatments.
Influence of oxygen uptake through the liver surface on the metabolism of ex vivo perfused liver during hypoxia.
Biochim Biophys Acta Gen Subj
October 2023
Article Synopsis
- Low-quality transplants affected by hypoxic injury can result in complications after surgery.
- This research uses mathematical modeling to analyze how oxygen absorption through the liver impacts its metabolism when oxygen levels are low.
- Findings indicate that lower oxygenation of the perfusion medium reduces oxygen uptake, requiring more energy for the liver's metabolism, while energy resources are optimally allocated among various metabolic processes.
Angiotensin I-converting enzyme (ACE) is a peptidase widely presented in human tissues and biological fluids. ACE is a glycoprotein containing 17 potential N-glycosylation sites which can be glycosylated in different ways due to post-translational modification of the protein in different cells. For the first time, surface-enhanced Raman scattering (SERS) spectra of human ACE from lungs, mainly produced by endothelial cells, ACE from heart, produced by endothelial heart cells and miofibroblasts, and ACE from seminal fluid, produced by epithelial cells, have been compared with full assignment.
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