Publications by authors named "O Kozlova"
Coronary heart disease (CHD) remains a leading cause of mortality among cancer patients, primarily due to shared risk factors and the impacts of chemotherapeutic drugs, immune checkpoint inhibitors, and radiotherapy. Determining the optimal treatment strategy remains a challenging issue for patients with concurrent CHD and malignant neoplasms. In high-risk patients, managing CHD frequently takes precedence over addressing the oncologic disease.
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- Lichens, key organisms in Arctic and boreal ecosystems, are sensitive to climate change, particularly increased UV light from ozone depletion and deforestation.
- This study investigates how UV-B radiation impacts gene expression in the lichen species Lobaria pulmonaria, highlighting significant browning of the upper cortex and activation of genes related to melanin production for stress protection.
- The findings reveal that lichen symbionts employ a complex gene network for tolerance to UV-B, suggesting that climate change could adversely affect lichen biodiversity through metabolic trade-offs and stress responses.
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- Carotid artery disease is common in patients with coronary heart disease, requiring revascularization options that include simultaneous or staged surgeries for treatment.
- A study involving 192 patients compared the outcomes of simultaneous coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA) versus staged procedures, assessing their 30-day and long-term effects on overall health.
- Results showed no significant differences in short-term and long-term major cardiovascular events between the two groups, but the simultaneous surgery group had a higher risk of complications and required longer ventilatory support, despite not leading to more deaths or major adverse events.
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- The study examines the role of SoxB transcription factors in the neurogenesis of gastropods, focusing on their expression patterns from gastrula to hatching.
- The researchers used various techniques to analyze the spatial and temporal expression of these factors and observed differences in their presence between developmental stages.
- The findings suggest that prolonged expression of SoxB genes may enhance neurogenesis in gastropods, potentially influencing the diversity of their nervous systems.
The analysis of telomere length is an important component of many studies aiming to characterize the role of telomere maintenance mechanisms in cellular lifespan, disease, or in general chromosome protection and DNA replication pathways. Several powerful methods to accurately measure the telomere length from Southern blots have been developed, but their utility for large-scale genomic studies has not been previously evaluated. Here, we performed a comparative analysis of two recently developed programs, TeloTool and WALTER, for the extraction of mean telomere length values from Southern blots.
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