Publications by authors named "O Konno"
We report the histological changes over time for a patient with infection-related glomerulonephritis (IRGN) that developed in a transplanted kidney. A 47-year-old man had undergone renal transplantation 3 years ago for end-stage kidney disease (ESKD). After several episodes of acute rejection, the patient was in a stable CKD condition.
View Article and Find Full Text PDFRationale: Reports have suggested a relationship between coronavirus disease 2019 (COVID-19) vaccination and new-onset or recurring renal diseases, of which immunoglobulin A (IgA) nephropathy is a representative disease. Alveolar hemorrhage in patients with IgA nephropathy is rare but reportedly has a high mortality and morbidity. To our knowledge, there have been no reports regarding the development of IgA nephropathy with alveolar hemorrhage following COVID-19 vaccination.
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- Glomerular lipidosis is a rare kidney condition characterized by lipid buildup in the glomeruli and can be associated with macrophage activation syndrome (MAS).
- A 42-year-old patient who underwent kidney transplantation developed proteinuria and high serum triglycerides, leading to a biopsy showing CD68 foam cells and CD3 T-cells, suggesting histiocytic involvement.
- The patient was diagnosed with renal-limited MAS and treated with lipid-lowering therapy, successfully normalizing triglyceride levels, while the effectiveness of immunosuppressants remained unchanged.
Article Synopsis
- - The text discusses a clinical trial on machine perfusion for kidney transplants in Japan, aiming to boost the use of this technique due to its potential benefits for organ preservation.
- - Thirteen kidney transplant procedures were performed using a specific machine that maintains optimal conditions for the organs, with details on donor types and recipient demographics highlighted.
- - The results indicated successful preservation with no primary non-functional cases, showing promise for machine perfusion as a method for using marginal donor organs in Japan.
Article Synopsis
- Early recovery in septic shock patients improves their overall prognosis, and the study explored whether Continuous Renal Replacement Therapy (CRRT) using polymyxin B (PMX-DHP) can stabilize their hemodynamics.
- 66 septic shock patients underwent PMX-DHP, with some receiving additional continuous hemodiafiltration (CHDF), and measurements of inflammatory cytokines (IL-6, IL-1ra, PAI-1) were taken before and after treatment.
- Results showed that PMX-DHP significantly increased Mean Arterial Pressure (MAP) and reduced cytokine levels, indicating that CRRT may be an effective strategy to improve outcomes in septic shock by modulating cytokine activity.