[MANAGEMENT OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN THE PREPREGNANCY AND ANTENATAL PERIODS: CHALLENGES AND SOLUTIONS (REVIEW)].

Systemic lupus erythematosus (SLE) is a rare, multi-systemic chronic autoimmune disease characterized by hyperproduction of organ-specific autoantibodies to various components of the cell nucleus with the development of immuno-inflammatory damage of tissues and internal organs, predominantly affecting women, particularly those of childbearing age. Hence future pregnancy is one of the key issues of the modern rheumatology. The management of the SLE patient should include an effective risk assessment of the future pregnancy and stratification followed by an individualized antenatal care program.

CHARACTERISTICS OF ARTICULAR SYNDROME IN SYSTEMIC VASCULITIS.

The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. The study included 525 patients in the ratio of the examined with Henoch-Schonlen purpura, microscopic polyangiitis, cryoglobulinemic vasculitis, polyarteritis nodosa, Takayasu's arteritis, Wegener's granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis Churg-Strauss as a 7:4:3:1:1:1:1. Joint's damage in the form of arthritis or arthralgia observed in 32-67% different groups of patients, that depending on the disease duration, the degree of the pathological process's activity, extraarticular signs severity, lung parenchyma involving and hemodynamic status in the pulmonary circulation.