Publications by authors named "O Kawamura"
Background: Although dysphagia and chest pain are the two most common symptoms in patients with achalasia, the mechanism of evoking symptoms is still unknown. The aim of this study was to reveal the relationship between symptoms and the subtypes of achalasia defined by the Chicago classification.
Methods: A total of 71consecutive patients with newly diagnosed achalasia were enrolled between March 2009 and December 2017.
In Japan, with the increasing prevalence of gastroesophageal reflux disease (GERD) and growing public interest, the Japanese Society of Gastroenterology issued Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009 and a revised 2nd edition in 2015. A number of studies on GERD were subsequently conducted in Japan and abroad, and vonoprazan, a potassium-competitive acid blocker (P-CAB), became available for the first time in Japan in February 2015. The revised 3rd edition (Japanese edition), which incorporates new findings and information, was published in April 2021.
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- * The research analyzed HRM studies from various global motility centers, finding that 74.6% of participants had normal results, with ineffective esophageal motility (IEM) being the most common abnormal finding (15.1%).
- * The study concluded that motor abnormalities are rare in healthy individuals, with IEM being the primary issue, and noted that thresholds for HRM measurements differ depending on the HRM system and whether the patient was upright or supine.
Background: Esophagogastric junction contractile integral (EGJ-CI) and EGJ morphology are high-resolution manometry (HRM) metrics that assess EGJ barrier function. Normative data standardized across world regions and HRM manufacturers are limited.
Methods: Our aim was to determine normative EGJ metrics in a large international cohort of healthy volunteers undergoing HRM (Medtronic, Laborie, and Diversatek software) acquired from 16 countries in four world regions.