Publications by authors named "O Kaniuka"
Upregulation of GRP78 is accompanied by decreased antioxidant response and mitophagy promotion in streptozotocin-induced type 1 diabetes in rats.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- Endoplasmic reticulum stress, oxidative stress, and mitochondrial dysfunction are linked processes that contribute to the development of diabetes mellitus, as shown in a study using two models: β-TC-6 cell line and rat models of type 1 diabetes.
- The study found that both models exhibit an increase in the GRP78 protein, which is associated with a stressed cellular environment, while also showing a breakdown in antioxidant systems and reduced ATP levels in pancreatic cells.
- The findings suggest that GRP78 upregulation under glucotoxic conditions leads to antioxidant depletion and promotes mitophagy, indicating that GRP78 might be a promising target for diabetes treatment.
Glucotoxicity is mediated by cytoplasmic distribution of RAP1 in pancreatic β-cells.
Arch Biochem Biophys
May 2024
Diabetes mellitus (DM) is a group of chronic metabolic disorders characterized by persistent hyperglycemia. In our study, we analyzed the level and location of RAP1 changes in the development of β-cell dysfunction induced by glucotoxicity. We employed three pancreatic β-cell lines, namely INS-1, 1.
View Article and Find Full Text PDFA pttg gene knockout affects the functional state of erythron in mice which could be associated with structural changes in the structure of erythrocyte membranes. The pttg gene knockout causes a significant modification of fatty acids composition of erythrocyte membrane lipids by reducing the content of palmitic acid and increasing of polyunsaturated fatty acids amount by 18%. Analyzing the erythrocyte surface architectonics of mice under pttg gene knockout, it was found that on the background of reduction of the functionally complete biconcave discs population one could observe an increase of the number of transformed cells at different degeneration stages.
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