Subchronic inhalation study of stone wool fibres in rats.

Pathology results after subchronic inhalation in rats of three separate fibres representing the new biosoluble high-aluminium low-silica HT type stone wool are given, and the results were compared with the results from a similar study done with the traditional stone wool MMVF21. Male Wistar rats were exposed at one exposure level by nose-only inhalation to well-characterized fibre test atmospheres. The fibres had been size selected to be largely rat respirable.

[Lung function and respiratory tract disease among stonewool factory workers].

Introduction: We examined the respiratory health of a Danish workforce exposed to man-made vitreous fibres (MMVF) during production.

Material And Methods: Workers with more than five years' occupational exposure to MMVF (n = 377) were compared to a group without MMVF exposure (n = 381). Respiratory health was assessed by questionnaire, dynamic spirometry, and measurement of transfer factor.

Carcinogenicity studies after intraperitoneal injection of two types of stone wool fibres in rats.

A summary is given of the pathology results after intraperitoneal (i.p.) injection in rats of insulation wool HT, representing the new biosoluble types.

High-alumina low-silica HT stone wool fibers: a chemical compositional range with high biosolubility.

Man-made vitreous fibers (MMVF) are classified within the European Union (EU) as carcinogenic category 3 (possibly carcinogenic), but criteria exist to exonerate fibers from this classification. The HT stone wool fiber type is a MMVF that fulfills European regulatory requirements for exoneration from classification as a carcinogen based on in vivo testing. The chemical composition of the fibers and the results of the in vivo and in vitro studies that defined the chemical compositional range for a CAS registry number for these fibers are presented and discussed.

Chronic inhalation studies of two types of stone wool fibers in rats.

A summary is given of the pathology results after long-term inhalation in rats of insulation wool representing the new biosoluble types. The pathology results are compared with previously conducted long-term inhalation study with MMVF21 (traditional stone wool). The biosoluble fiber MMVF34/HT (HT) is characterized by a relatively high content of aluminum and a relatively low content of silica compared to the older MMVF21.