Mitigation of magnetic particle hyperthermia side effects by magnetic field controls.

In magnetic particle hyperthermia, a promising least-invasive cancer treatment, malignant regions in proximity with magnetic nanoparticles undergo heat stress, while unavoidably surrounding healthy tissues may also suffer from heat either directly or indirectly by the induced eddy currents, due to the developed electric fields as well. Here, we propose a facile upgrade of a typical magnetic particle hyperthermia protocol, to selectively mitigate eddy currents' heating without compromising the beneficial role of heating in malignant regions. The key idea is to apply the external magnetic field intermittently (in an ON/OFF pulse mode), instead of the continuous field mode typically applied.

Biogenic selenium nanoparticles produced by ATCC 393 inhibit colon cancer cell growth and .

Selenium compounds exhibit excellent anticancer properties but have a narrow therapeutic window. Selenium nanoparticles, however, are less toxic compared to other selenium forms, and their biogenic production leads to improved bioavailability. Herein, we used the probiotic strain ATCC 393, previously shown to inhibit colon cancer cell growth, to synthesize biogenic selenium nanoparticles.

Rapid Millifluidic Synthesis of Stable High Magnetic Moment FeC Nanoparticles for Hyperthermia.

A millifluidic reactor with a 0.76 mm internal diameter was utilized for the synthesis of monodisperse, high magnetic moment, iron carbide (FeC) nanoparticles by thermal decomposition of iron pentacarbonyl (Fe(CO)) in 1-octadecene in the presence of oleylamine at 22 min nominal residence time. The effect of reaction conditions (temperature and pressure) on the size, morphology, crystal structure, and magnetic properties of the nanoparticles was investigated.

The Effect of Polyol Composition on the Structural and Magnetic Properties of Magnetite Nanoparticles for Magnetic Particle Hyperthermia.

A study of the influence of polyols, with or without an additional reducing agent, on crystallites' size and magnetic features in FeO nanoparticles and on their performance in magnetic particle hyperthermia is presented. Three different samples were synthesized by thermal decomposition of an iron precursor in the presence of NaBH in a polyol. So far, triethylene glycol (TrEG) and polyethylene glycol (PEG 1000 and PEG 8000) that exhibit different physical and chemical properties have been used in order to investigate the influence of the polyols on the composition and the size of the NPs.

Improving the Subcutaneous Mouse Tumor Model by Effective Manipulation of Magnetic Nanoparticles-Treated Implanted Cancer Cells.

Murine tumor models have played a fundamental role in the development of novel therapeutic interventions and are currently widely used in translational research. Specifically, strategies that aim at reducing inter-animal variability of tumor size in transplantable mouse tumor models are of particular importance. In our approach, we used magnetic nanoparticles to label and manipulate colon cancer cells for the improvement of the standard syngeneic subcutaneous mouse tumor model.