The effect of Andaliman ( DC.) fruit extracted with ethanol on TNF-α and TRPA-1 levels in type II diabetes-induced mice.

Objective: The present study investigated the effects of Andaliman fruit extract on tumor necrosis factor-alpha (TNF-α) and transient receptor potential ankyrin-1 (TRPA-1) levels in type 2 diabetes mellitus (T2DM) mouse models induced with streptozocin (STZ) and a high-fat diet (HFD).

Materials And Methods: In this research, mice were allocated into six distinct groups: normal, negative control (HFD and STZ), positive control (metformin, HFD, and STZ), and three treatment groups (HFD, STZ, and Andaliman extract at varying dosages of 100, 300, and 500 mg/kg, respectively). Body weight and blood glucose levels (BGLs) were recorded at weeks 1 (baseline), 8, 12, and 16.

Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritis rat model.

Objective: This research work aimed to assess the histopathological features and degree of gastritis severity in a rat model, induced by infection after administering omeprazole, amoxicillin, and clarithromycin as the standard first-line eradication regimen.

Material And Methods: Twenty-one male rats were adapted for 7 days and randomly divided into three equal groups. Group 1 was considered a negative control.

The effect of extract and standard eradication regimen on asymmetric dimethylarginine in gastritis rat model.

Background And Aim: The presence of gastric mucosa or submucosa inflammation due to leads to histological changes. Gastric injury, pro-inflammatory factors, and oxidative stress in infection produce asymmetric dimethylarginine (ADMA), which are a competitive inhibitor of nitric oxide synthase. Investigations were carried out aimed at finding new drugs derived from natural products for the treatment of .

The effect of snakehead fish extract supplementation to first-line eradication regimen on macrophage migration inhibitory factor (MIF) expression in rats induced by infection.

Objective: This work was organized to assess macrophage migration inhibitory factor (MIF) expression in snakehead fish extract supplementation to first-line eradication regimen in rats induced by infection.

Materials And Methods: A total of 28 manly rats were haphazardly isolated equally into four groups. Group-1 was the control negative, and groups-2-4 were -infected groups.

Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups.

Indonesia is a big country with multiethnic populations whose gastric cancer risks have not been elucidated. We performed a nationwide survey and obtained histological specimens from 1053 individuals in 19 cities across the country. We examined the gastric mucosa, the topography, the atrophic gastritis risk factors, and the gastric cancer risk scores.