Publications by authors named "O J Semmes"
Article Synopsis
- Benign prostatic hyperplasia (BPH) is a common age-related condition causing severe urinary issues, linked to hormonal imbalances such as elevated estradiol and testosterone levels.
- Previous research in mice revealed that these hormonal changes lead to increased macrophage accumulation in the prostate, where they transform into foam cells.
- The current study identified specific macrophage subtypes and their gene expression signatures in response to hormone imbalance, while also finding that a protein called Cxcl17 might encourage macrophages to enter the prostate lumen.
Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort.
Cancer Epidemiol Biomarkers Prev
November 2024
Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to underestimation of tumor grade. To study the clinical, epidemiologic, and molecular hallmarks of this phenomenon, we conducted a prospective study of grade upgrading: differences in detected prostate cancer grade between biopsy and surgery.
View Article and Find Full Text PDFProstate cancer is a significant health problem in the United States. It is remarkably heterogenous, ranging from slow growing disease amenable to active surveillance to highly aggressive forms requiring active treatments. Therefore, being able to precisely determine the nature of disease and appropriately match patients to available and/or novel therapeutics is crucial to improve patients' overall outcome and quality of life.
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- Urine shows how healthy someone is and gives clues about the health of the organs that create it, containing both secreted proteins and proteins in tiny bubbles called extracellular vesicles (EVs).
- Scientists studied the urine proteins of 190 men, including some with prostate cancer, and found a method to better collect prostate-related proteins from urine.
- The research shows that urine can help tell the difference between serious and less serious prostate issues and that these urine proteins stay pretty consistent over the years, which is useful for medical studies.
Introduction: Aberrant glycosylation of proteins is an important hallmark in multiple cancers. Prostate-specific membrane antigen (PSMA), a highly glycosylated protein with 10 N-linked glycosylation sites, is an Food and Drug Administration approved theranostic for prostate cancer. However, glycosylation changes in PSMA that are associated with prostate cancer disease progression have not been fully characterized.
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