Publications by authors named "O J Neira"
Factors predictive of severe thrombocytopenia and its impact on poor outcomes in Latin American patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort.
Semin Arthritis Rheum
December 2024
Objective: To examine the predictors of the occurrence of severe thrombocytopenia and its impact on damage accrual and mortality in SLE patients.
Methods: Factors associated with time to severe thrombocytopenia (platelet count ≤20,000/mm) occurring from the onset of SLE symptoms were assessed by Cox proportional hazards regressions. The association of severe thrombocytopenia with mortality was evaluated by logistic regression analyses while its impact on damage was by negative binomial regression.
Objectives: To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.
Methods: The first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization.
Article Synopsis
- - The study investigates the characteristics and effects of the time taken to diagnose systemic lupus erythematosus (SLE) in a Latin American cohort, noting that diagnosis can often be delayed and that SLE may resemble other diseases.
- - Patients with longer diagnosis times (over 6 months) were often older, female, of Mestizo descent, uninsured, and displayed atypical symptoms, but this delayed diagnosis did not seem to affect their disease progression or mortality rates significantly.
- - Overall, the research concludes that within this cohort, waiting up to 24 months for an SLE diagnosis, with a median of 6 months, did not lead to worse health outcomes.
Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort.
J Clin Rheumatol
March 2024
Article Synopsis
- The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is a promising development, but previous studies primarily focused on White and Asian populations, highlighting the need for research in Latin America.
- A study collected medical records from 300 patients across multiple Latin American countries, finding that 66.7% of IgG4-RD cases were accurately identified by the 2019 AECC, with specificity reaching 100%.
- Although the criteria were effective in identifying true cases, the presence of other autoimmune diseases and certain autoantibodies limited its sensitivity, suggesting the criteria may exclude some patients who actually
Article Synopsis
- This study examined the predictors and consequences of severe autoimmune hemolytic anemia (AIHA) in patients with systemic lupus erythematosus (SLE).
- Among 1,349 SLE patients, 3.6% developed severe AIHA over an average follow-up of 5.4 years, with male sex and higher initial disease activity linked to a quicker onset.
- Interestingly, while hematological issues showed a trend towards significance in predicting severe AIHA, the occurrence of severe AIHA did not appear to significantly influence damage or mortality in these patients.