Publications by authors named "O J Martin"
Purpose: Both local tumor control and distant metastasis are important indicators of the efficacy of radiation therapy treatment. Synchrotron microbeam radiation therapy (MRT), spatially fractionated radiation delivered at ultrahigh dose rates, shows remarkable normal tissue sparing with excellent local control in some models. Some MRT regimens trigger an antitumor immune response that contributes not only to the local but also to systemic treatment efficacy.
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- The study investigates how the reproductive success of Alpine and Saanen goats using artificial insemination (AI) relates to their lactation performance over time.
- Researchers analyzed data from two French farms spanning 1996-2021, focusing on milk yield, body weight, and body condition scores to understand their impact on AI success.
- Results indicate that the shape of lactation curves is more critical for AI success than just the amount of milk produced, highlighting the importance of factors like persistency and body weight recovery for improving reproductive performance in dairy goats.
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- In situ hybridization is a method used to visualize RNA in cells, but analyzing images can be complicated.
- The presented protocol utilizes open-source software for automating the analysis of multiple RNA probes (up to 14) in fluorescence in situ transcriptomics.
- Key steps involve segmenting cell nuclei, storing raw data, ensuring quality control, and using a Python app to compile results into a comprehensive spreadsheet that shows cell positivity.
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- Lifespan variability exists within species, including genetically identical Caenorhabditis elegans, indicating factors beyond genotype and environment influence longevity.
- Researchers identified biomarkers that strongly predict lifespan, some being positively correlated (lin-4p::GFP, mir-243p::GFP) and others negatively correlated (mir-240/786p::GFP, autofluorescence), suggesting a shared health state linked to longevity.
- The study revealed that even among individuals of the same chronological age, those predicted to be long- or short-lived had notable differences in their gene expression profiles, indicating that lifespan predictions involve more than just typical aging processes.
Despite the recent progress, current treatment modalities are not able to eradicate cancer. We show that Microbeam Radiotherapy (MRT), an innovative type of Spatially Fractionated Radiotherapy, can control murine melanoma by activating the host's own immune system. The beneficial effects are very pronounced in comparison to uniform radiotherapy traditionally employed in the clinic.
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