Publications by authors named "O J Kim"
Microbial metabolites provide numerous benefits to the human body but can also contribute to diseases such as obesity, diabetes, cancer, and bone disorders. However, the role of imidazole propionate (ImP), a histidine-derived metabolite produced by the intestinal microbiome, in bone metabolism and the development of osteoporosis is still poorly understood. In this study, we investigated the role of ImP and its underlying mechanisms in regulating bone homeostasis.
View Article and Find Full Text PDFWhile methyl-tertiary butyl ether (MTBE) remains the sole clinical topical agent for gallstone dissolution, its utility is limited due to side effects, largely stemming from its relatively low boiling point (55°C). In this study, we introduced 2-methoxy-6-methylpyridine (MMP), a novel gallstone-dissolving compound featuring an aromatic moiety and a substantially higher boiling point (156°C), designed to mitigate these side effects. We conducted a comprehensive evaluation of the efficacy and potential toxicities of MMP compared to MTBE using both in vitro and in vivo models.
View Article and Find Full Text PDFTo identify the prevalence and risk factors for low bone density (LBD) in young adults with spinal cord injury (SCI). Retrospective cross-sectional study. National Rehabilitation Center in Seoul, Korea.
View Article and Find Full Text PDFArticle Synopsis
- Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease, and accurately diagnosing it in spinal cord injury (SCI) patients is crucial for prevention.
- A study analyzed data from 2015 to 2019 to compare MetS prevalence in SCI patients versus the general population, finding that SCI patients had a significantly higher prevalence.
- Factors like older age and lower income were linked to MetS in both groups, while lifestyle factors such as smoking and alcohol use were more significant in the general population, highlighting the need for tailored diagnostic criteria for SCI patients.
Article Synopsis
- Recent advancements in nanomedicine have shown that exosome-based therapies could be effective for targeted cancer treatment, particularly in colon cancer.
- A study explored the effectiveness of siPIN1-loaded exosomes that target a specific ligand (sAPRIL) in cancer models, demonstrating that these engineered exosomes have enhanced anticancer properties.
- Results indicated that the tEx[p] group, which had the siPIN1 RNA loaded, significantly reduced tumor size and growth compared to other treatments, suggesting a promising new strategy for colon cancer therapy.