Publications by authors named "O J Brady"
Background: Most longitudinal studies of COVID-19 incidence have used unlinked samples. The city of Manaus, Brazil, has a blood donation program which allows sample linkage, and was struck by two large COVID-19 epidemic waves between mid-2020 and early 2021.
Methods: We estimated the changing force of infection, i.
Access to allogeneic and autologous hematopoietic stem cell transplantation (SCT) remains inadequate despite its curative potential across hematologic malignancies. In 2015, Hartford HealthCare (HHC) and the Memorial Sloan Kettering Cancer Center (MSK) established the Shared Care Model (SCM) with a primary aim of enhancing SCT access for HHC patients. The SCM comprises several components: an SCT-dedicated nurse-navigator, a health-information exchange for record sharing, telemedicine, and ongoing training of HHC clinicians in transplant patient selection and management.
View Article and Find Full Text PDFBackground: People of African and Caribbean heritage in the UK have a higher prevalence of Type 2 Diabetes (T2D) and poorer health outcomes than white Europeans. Healthy Eating and Active Lifestyles for Diabetes Online (HEAL-D Online) is a co-designed, culturally tailored T2D self-management programme for black African and Caribbean adults, which, due to online delivery, is well positioned for spread. This qualitative evaluation uses the Exploration-Preparation-Implementation-Sustainment (EPIS) framework to explore factors affecting scale-up from delivery and commissioning perspectives.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes the effectiveness of monitoring visceral leishmaniasis (VL) on a village level in Bihar, India, highlighting challenges with resource-intensive surveillance as cases decline.
- The researchers tested a statistical method to estimate VL incidence at the village level from block-level data, finding that this approach didn't provide more accurate estimates than assuming uniformity within blocks.
- The findings suggest that while reactive interventions may not be effective for neighboring villages, maintaining surveillance in areas at risk of population movement could help prevent the spread of VL into currently unaffected areas.
Background: The global prevalence of diseases transmitted by mosquitoes, such as dengue, Zika and Yellow Fever, is increasing, but development of promising new mosquito control technologies could reverse this trend. Target Product Profiles (TPPs) and Preferred Product Characteristics (PPCs) documents issued by the World Health Organization can guide the research and development pathways of new products and product combinations transitioning from proof of concept to operational use.
Methods: We used high resolution global maps of the case and economic burden of dengue to derive programmatic cost targets to support a TPP for replacement.