Publications by authors named "O Iwata"

Article Synopsis
  • Hypoxic-ischemic encephalopathy (HIE) is a serious condition leading to high mortality and neurological issues, currently only treatable with therapeutic hypothermia.
  • A clinical trial was conducted using Muse cells (CL2020) in 9 neonates with moderate-to-severe HIE, who also received therapeutic hypothermia; safety and tolerability were the main goals.
  • The trial found that CL2020 was safe, with no severe adverse effects and normal developmental outcomes in about 67% of patients, indicating a need for further research through a larger controlled study to confirm these results.
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Supraglottic airway devices such as laryngeal masks and i-gels are useful for airway management. The i-gel is a relatively new device that replaces the air-inflated cuff of the laryngeal mask with a gel-filled cuff. It remains unclear which device is more effective for neonatal resuscitation.

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Subtle changes in body temperature affect the outcomes of ill newborns. However, the temperature profile of neonatal brains remains largely unknown. In open-cot care, increased cerebral perfusion is correlated with higher superficial brain temperatures.

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Article Synopsis
  • * A retrospective analysis of 248 VLBWIs suggested that factors such as gestational age, birth weight, and enteral nutrition impact citrulline levels over time, indicating that these levels change as infants mature.
  • * Citrulline levels appear to reflect a shift from catabolism (breaking down) to synthesis (building up) that occurs as fetal growth progresses and after birth, positioning citrulline as a potential indicator for assessing intestinal health.
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Introduction: Respiratory morbidities in neonates are often progressive and life-threatening, and its early prediction is crucial. Intrauterine inflammation is one of the key control variables of respiratory morbidities in both very preterm and term neonates; however, little is known about its effects in the remaining group of moderate-to-late preterm neonates born between 32+0 and 36+6 weeks of gestation. This study aimed to confirm whether intrauterine inflammation is associated with respiratory morbidities in moderate-to-late preterm neonates.

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