[The influence of mexidol on the liver functions, structure, and parameters of lipid peroxidation under long-term hypodynamia conditions].

It is established that rabbits kept under the conditions of 30-day hypodynamia with high-grade feeding exhibit disorders in both structure and functions of the liver, which are classified as nonalcoholic type fatness. Other disturbances are an increase in the activity of aspartate aminotransferase (AsAT) and alanine aminotransferase (AlAT) and a decrease in the total protein content predominantly at the expense of albumin. The development of a syndrome of mesenchymal inflammation is manifested by a relative growth of the alpha1, alpha2 and gamma-protein fractions.

[Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinate of the hepatotoxyc, caused at rats introduction tuberculostatics].

Administration of toxic doses of means specific tuberculostatics chemotherapy to rats caused development of medicinal damages of liver, kidneys, and pancreas. Use of 2-ethyl-6-methyl-hydroxypyridine succinate (SEMOP) and S-adenosyl-L-methionine reduced manifestations of pathological effects of tuberculostatics an organism of laboratory animals. There was clear dose-dependence of SEMOP effects.

[Optimization of geriatric help for urban and rural residents of the Ulianovsk region].

The problem of ageing of the population presupposes the necessity of essential in medico-social services activity and the creations of some uniform coordinated help system for the slderly within the framwork of public health sevices anf social protection. On the basis of the carried out analysis of demographic, social, economic and medical parameters we have developed the plan of geriatric service in Ulyanovsk area. Ulyanovsk Regional Clinical Hospital of War Veterans took the leading part in this work.

[Effect of mexidol on the homeostasis and lipid peroxidation in paracetamol poisoning].

It is established that mexidol (3-hydroxy-6-methyl-2-ethylpyridine succinate) influences the state of homeostasis in guinea pigs intoxicated with paracetamol. Paracetamol administered in toxic doses disturbs the functions of liver and kidneys, violates the lipid, carbohydrate, and mineral metabolism, activates the lipid peroxidation (LPO) process, and decreases the level of antioxidant protection. Treatment of the test animals with mexidol (25 mg/kg) decreases the cytolysis of hepatocytes, the development of cholestasis, the degree of hepatocellular insufficiency, the growth of endogenous intoxication, the drop of calcium content, the growth of iron content in the blood serum, and the content of final LPO products.

[Use of the plant hepatoprotector Galstena tuberculostatics-induced hepatic lesions: experimental and clinical study].

The efficiency of the use of the natural drug Galstena (Richard Bittner GmbH) was experimentally and clinically studied on a model of damage induced by toxic doses of tuberculostatics (rifampicin, isoniazid, pyrazinamide) in laboratory rats and in patients with different forms of pulmonary tuberculosis and with hepatitis caused by specific antituberculous drug therapy, who were treated at the Clinic of Phthiziology. Galstena was found to have marked hepatoprotective properties and to be able to prevent renal and pancreatic disorders. The drug also showed an antioxidative activity.