Publications by authors named "O Irtyuga"
Article Synopsis
- This study investigated thrombotic and hemorrhagic complications during pregnancy, delivery, and postpartum in women with prosthetic heart valves (PHV), covering 88 pregnancies from January 2011 to December 2022.
- Of the pregnancies, 79 resulted in live births, with higher miscarriage rates in the mechanical valve prosthesis (MVP) group compared to the biological valve prosthesis (BVP) group, alongside notable thrombotic complications predominantly in the MVP group.
- While effective anti-factor Xa activity control was noted to reduce thrombotic events, the study highlighted a concerning rate of postpartum hemorrhagic complications, suggesting a need for revising anticoagulant therapy protocols.
The NOTCH-signaling pathway is responsible for intercellular interactions and cell fate commitment. Recently, NOTCH pathway genes were demonstrated to play an important role in aortic valve development, leading to an increased calcified aortic valve disease (CAVD) later in life. Here, we further investigate the association between genetic variants in the NOTCH pathway genes and aortic stenosis in a case-control study of 90 CAVD cases and 4723 controls using target panel sequencing of full-length 20 genes from a NOTCH-related pathway (, , , , , , , , , , , , , , , , , , , ).
View Article and Find Full Text PDFAortic stenosis (AS) is the most commonly diagnosed valvular heart disease, and its prevalence increases with the aging of the general population. However, AS is often diagnosed at a severe stage, necessitating surgical treatment, due to its long asymptomatic period. The objective of this study was to analyze the frequency of AS in a population of cardiovascular patients using echocardiography (ECHO) and to identify clinical factors and features associated with these patient groups.
View Article and Find Full Text PDFArticle Synopsis
- Aortopulmonary window is a rare congenital heart defect leading to severe complications like pulmonary arterial hypertension and heart failure, making pregnancy extremely risky.
- Two case studies are presented involving pregnant women with this defect, one resulting in maternal death postpartum, while the other survived with continued treatment.
- The article emphasizes the importance of specialized care for these patients due to the unique challenges and high risks associated with their condition during pregnancy.
Article Synopsis
- Late pulmonary autograft dilatation occurs in 10-20% of Ross procedure patients, often requiring a redo procedure like composite aortic replacement or valve-sparing root replacement, which avoids lifelong anticoagulation.
- A reported case showed a patient with 60 mm dilatation after 20 years, leading to successful elective valve-sparing root replacement (David I procedure) with minimal complications.
- This procedure is effective for managing late pulmonary autograft failure while preserving native valve leaflets, reducing risks of aortic regurgitation and heart-related issues.