Embolic complications in a large contemporary cohort of infective endocarditis: do we need score model?

Purpose: Infective endocarditis (IE) is a heterogeneous disease undergoing epidemiological changes. Whether those changes have an impact on the correlates of embolic events (EE) remains unclear. We analyzed the correlates of EE and proposed a diagnostic score model in a large contemporary cohort.

A supergene controls facultative diapause in the crop pest Helicoverpa armigera.

Many insect species, including the economically important pest Helicoverpa armigera, avoid unfavorable conditions by suspending development. This form of phenotypic plasticity-facultative diapause-is a complex trait, though its evolution and intricate genetic architecture remain poorly understood. To investigate how such a polygenic trait could be locally adapted, we explore its genetic architecture.

Impact of organic contaminants in soils from Important Bird and Biodiversity areas.

Soils act as sinks for many organic contaminants, posing a threat to biodiversity and essential ecosystem services. In this study, we assessed the contamination status of soils in 140 Important Bird and Biodiversity Areas (IBAs) in Spain. Fifty-two organic contaminants including organochlorine pesticides (OCPs), organophosphorus pesticides (OPPs), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and plasticizers or plastic related such as phthalates, bisphenol A, nonylphenol, and organophosphate esters (OPEs) were analyzed by gas chromatography coupled to tandem mass spectrometry (GC-MS/MS).

A pipeline for STED super-resolution imaging and Imaris analysis of nanoscale synapse organization in mouse cortical brain slices.

Advances in super-resolution imaging enable us to delve into its intricate structural and functional complexities with unprecedented detail. Here, we present a pipeline to visualize and analyze the nanoscale organization of cortical layer 1 apical dendritic spines in the mouse prefrontal cortex. We describe steps for brain slice preparation, immunostaining, stimulated emission depletion super-resolution microscopy, and data analysis using the Imaris software package.