Publications by authors named "O Igoucheva"
Recessive dystrophic epidermolysis bullosa (RDEB) patients develop poorly healing skin wounds that are frequently colonized with microbiota. Because T cells play an important role in clearing such pathogens, we aimed to define the status of adaptive T cell-mediated immunity in RDEB wounds. Using a non-invasive approach for sampling of wound-associated constituents, we evaluated microbial contaminants in cellular fraction and exudates obtained from RDED wounds.
View Article and Find Full Text PDFArticle Synopsis
- Hereditary epidermolysis bullosa (EB) is a skin disorder that makes the skin very fragile, causing painful blisters when it gets hurt.
- There are different types of EB, but there's no cure, and people with a certain type (RDEB) have painful sores that don't heal well and can get infected.
- To help RDEB patients feel better, scientists need to understand how their body responds to infections and what goes wrong with their immune system when they have these chronic wounds.
Vitiligo is an acquired pigmentary skin disorder that currently lacks standardized treatment and validated biomarkers to objectively evaluate disease state or therapeutic response. Although prior studies have linked vitiligo autoimmunity with CXCL10/CXCL9-mediated recruitment of leukocytes to the skin, only limited clinical data are available regarding CXCL10 as vitiligo biomarker. To evaluate the utility of systemic CXCL10 as a predictor of disease progression and treatment response on a large cohort of vitiligo patients.
View Article and Find Full Text PDFPathogenic invasion of Staphylococcus aureus is a major concern in patients with chronic skin diseases like atopic dermatitis (AD), epidermolysis bullosa (EB), or chronic diabetic foot and venous leg ulcers, and can result in persistent and life-threatening chronic non-healing wounds. Staphylococcus aureus is generally recognized as extracellular pathogens. However, S.
View Article and Find Full Text PDFBackground: Poorly healing wounds are one of the major complications in patients suffering from recessive dystrophic epidermolysis bullosa (RDEB). At present, there are no effective means to analyze changes in cellular and molecular networks occurring during RDEB wound progression to predict wound outcome and design betted wound management approaches.
Objectives: To better define mechanisms influencing RDEB wound progression by evaluating changes in molecular and cellular networks.