[Production of superoxide anion radical and nitric oxide in renal tissues sutured with different surgical suture material].

The generation of superoxide anion radicals (in mitochondria, microsomes and under respiratory burst of leucocytes) and nitric oxide (NO) in renal tissue has been studied in the experiment with white rats, which had been carried out nephrotomy with following usage for suture such absorbable surgical threads as plain and chromic catgut, biofil (of dura mater spinalis of the cattle), Dexon II (polyglycolic acid) and biofil modified with aethonium, succinate and mexidol. The research proves the use of plai and chromic catgut leads to the development longer oxidative stress with increasing of cytotoxic agents production (superoxide anion and NO). The risk of longitudinal oxidative stress decreases under the use of biofil suture modified with biological active compounds (aethonium, succinate and mexidol).

[Changes in the level of DNA minor bases in salivary gland inflammation and its correction with antioxidants].

In the experiment with guinea pigs at contact sialoadenitis reproduction (karragenine inflammation of soft tissues of the oral cavity) it was established that in DNA of salivary glands cells and the neighbouring tissues the content of 5-methylcytosine was decreased, it being normalized at "Triovit" antioxidant complex together with cvercitynum correction. The content of DNA 8-hydroxyguanine is characterized by a wide range of data and in absolute values increases in inflammation, but decreases after antioxidant correction. The role of the changes discovered is discussed.

[The sources of active forms of oxygen in the normal oral tissues and in pathology].

In the experiment on rats the changes of the superoxydanionradical production from microsomal and mitochondrial oxidation and tissue phagocytes of the saliva gland and parodontium in contact sialadenitis, spontaneous parodontitis, after ionizing radiation have been investigated. It is supposed that an increase or decrease of superoxydanionradical production from different sources demands a differentiated corrective approach.

[The antioxidant system of patients with chronic inflammatory liver diseases after exposure to ionizing radiation].

Commonly seen in liquidators of the effects of the Chernobyl accident are affections of the liver (chronic hepatitis) and bile tract (chronic calculous cholecystitis) accompanied by IHD. The above patients demonstrate enhancement of the antioxidant defence in the blood with the values for free-radical peroxidation remaining unchanged. Absolute values for blood content of LTV4 in chronic active hepatitis were found out to be low, which fact suggests that such patients need to be kept under periodic oncological surveillance.

[Antioxidant status in manganese poisoning].

Pigs intoxication by chloride manganese in dose 50 mg/kg perk day for 10 days brings to lowering antioxidant protection in blood and the level of respiratory neutrophils' burst. In liver and kidneys superoxide dismutase activity increases, in liver--increasing of initiate and final malondialdehyde contents and lowering of concentration of restored glutathione and ATP.