Publications by authors named "O I Trofimova"
The requirement for the development of advanced technologies is the need to create new functional thermostable soluble polysilsesquioxanes. Combining the potential of organosilicon chemistry and the chemistry of heterocyclic compounds is a promising direction for the formation of novel organosilicon polymer systems with new properties and new possibilities for their practical application. Using the classical method of hydrolysis and polycondensation of previously unknown trifunctional (trimethoxysilylpropyl)glutarimide in the presence or absence of an acid or base catalyst, a universal approach to the formation of new thermostable soluble polysilsesquioxanes with glutarimide side-chain groups is proposed, which forms the basis for the synthesis of polysilsesquioxane polymers with different functionality.
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- Fundus images help assess retinal blood vessels non-invasively, allowing researchers to extract 17 different vascular characteristics from over 130,000 images of UK Biobank subjects.
- Genetic studies reveal that the heritability of these vascular traits ranges from 5% to 25%, and there are distinct genetic links among the traits, indicating different biological mechanisms at play.
- The research identifies specific vascular features linked to health issues like heart attack and suggests that factors like blood pressure and body mass index may influence retinal vessel shapes.
Despite major advances, our understanding of the neurobiology of life course socioeconomic conditions is still scarce. This study aimed to provide insight into the pathways linking socioeconomic exposures-household income, last known occupational position, and life course socioeconomic trajectories-with brain microstructure and cognitive performance in middle to late adulthood. We assessed socioeconomic conditions alongside quantitative relaxometry and diffusion-weighted magnetic resonance imaging indicators of brain tissue microstructure and cognitive performance in a sample of community-dwelling men and women ( = 751, aged 50-91 years).
View Article and Find Full Text PDFSoluble polysilsesquioxane containing side-chain phthalimide groups (PSQ-PhI) was synthesized via a solvent- and catalyst-free hydrolytic polycondensation reaction using 2-[3-(triethoxysilyl)propyl]-1-isoindole-1,3(2)-dione. The composition and structure of polysilsesquioxane was confirmed via H, C, and Si NMR spectroscopy, Fourier transform infrared spectroscopy, gel permeation chromatography, thermogravimetric analysis, dynamic light scattering, X-ray diffraction analysis, and elemental analysis. The synthesized silsesquioxane showed a monomodal molecular weight distribution.
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- The study explores how cardiovascular risk factors (CVRFs) like hypertension and obesity affect the brain's white matter microstructure using MRI data from over 1,100 participants aged 46-87.
- Hypertension was linked to lower myelin and axonal density, while obesity affected myelin density in male participants only, particularly in specific brain tracts related to emotional and executive functions.
- The results suggest that physical activity improves myelin content and highlight that changes in the brain are more about myelin loss and neuroinflammation rather than traditional neurodegeneration.