[ESTIMATION OF THE QUALITY OF DRINKING PIPELINED WATER BY THE DEGREE OF CONTAMINATION WITH MICROSCOPIC FUNGI].

The analysis of literature and water data on the presence of microbiological safety indicators of micromycetes was conducted, that are able to exist and reproduce in tap water entering the consumer. Microscopic fungi (Penicillium, Rhodotorula, Fusarium, Cladosporium, Aspergillus) in the amount of 10 to 303,3 CFU/dm3 were detected in the samples of tap drinking water studied. At the same time, tap water in 50.

[Health and environment: the need and opportunity for the evaluation of the influence of environmental factors on the state of the population genofond in Ukraine].

In connection with the drastically changed the human environment, including in connection with pollution by mutagenic and teratogenic factors of different origin, the majority of the population, including in Ukraine, is posed in different living conditions in comparison with previous generations. The recognizance of epigenetic impacts and the possibility of their inheritance significantly increased the role of environmental factors in ensuring human health of both present and future generations. There has been proposed the system of assessment of the status and reproduction of the genofond of the population consisting of assessment of the level of natality, determination of the proportion of persons of optimal reproductive age and children, calculation of the frequency and risk of congenital malformations, spontaneous abortions of the first trimester of gestation, infertile marriages, as well as identification of priority risk factors of formation of pathology, analysis of anthropometric parameters of newborns and comparison them with data characterizing the previous generation.

[Birth defects on Chernobyl radionuclide polluted territories].

147318 pregnancy outcomes were analyzed in Zhytomyrska Oblast during 2000-2010; the descriptive analysis was performed. The frequency of birth defects was estimated among newborns, still-born babies and abortions due to genetic disorders of a fetus on "clean" and polluted territories. There was an increase of all birth defects on the polluted territories; among newborns it was (26.

[Proteomic technologies for identification of serum potential biomarkers of autoimmune demyelinating polyneuropathies].

Time-of-flight MALDI mass spectrometry (MALDI-TOF-MS) profiling of blood serum of patients with Guillain-Barré syndrome (GBS, 36 samples), chronic inflammatory demyelinating polyneuropathy (CIDP, 24 samples) and practically healthy donors (HD) (35 samples) was carried out in order to identify potential biomarkers of autoimmune demyelinating polyneuropathies (ADP). To simplify the peptide-protein mixture of serum prior to MALDI-TOF-MS analysis samples were pre-fractionated on magnetic microparticles with a weak cation-exchange (MB-WCX) surface. Comparative analysis of mass spectrometric data using the classification algorithms (genetic and neural network-controlled) revealed a characteristic set of peaks, agreed change area with a high specificity and sensitivity of the differentiated mass spectrometry profiles of the blood serum of patients with DPNP and healthy donors (for GBS values of these characteristics reached 100 and 100, and for CIDP 94.