[Prospects for the use of ozone therapy and low-intensity laser therapy in the treatment of atrophic pharyngitis].

Unlabelled: Chronic pharyngitis (CP) is one of the most common diseases of the oropharynx. The number of referrals from patients with CP reaches 70% of the total number of referrals to an otorhinolaryngologist. The development of this disease is facilitated by the neuro-reflex factor and a violation of trophic and metabolic processes.

The role of cholesterol in the exo- and endocytosis of synaptic vesicles in frog motor nerve endings.

Experiments on frog neuromuscular preparations using electrophysiological (two-electrode voltage clamping) and optical (with the fluorescent endocytic stain FM1-43) methods were performed to study the importance of membrane cholesterol in the exo- and endocytic cycle of synaptic vesicles (SV) in motor nerve endings in conditions of prolonged rhythmic stimulation of the motor nerve (20 impulses/sec, 3 min). Extraction of cholesterol from the superficial plasma membranes using methyl-beta-cyclodextrin (1 mM) led to marked changes in SV recycling. There was weakening of SV exocytosis and suppression of processes leading to the recovery of SV populations with rapid readiness to release neurotransmitter.

[The role of cholesterol in exo- and endocytosis of the synaptic vesicles at the frog motor nerve terminal].

In experiments on the frog neuro-muscular preparations using electrophysiological (two electrode fixing of potential) and optical (fluorescent endocytic dye FM1-43) methods, the value of surface cholestertol for exo-endocytic cycle of synaptic vesicles at the prolonged rhythmic activity (20 Hz--3 minutes) was investigated. It is shown that extraction of cholesterol from surface membranes by methyl-betta-cyclodextrin (1 mM MCD) leads to the expressed shifts in recycling of synaptic vesicles. Exocytosis of vesicles is decreased, and oppression of processes leading to restoration of the number of vesicles of ready releasable pool is observed.

[Effect of lower limb critical ischaemia on course of wound process and incidence rate of high amputations in pyonecrotic forms of diabetic foot syndrome].

Analysed herein are therapeutic outcomes in a total of 417 patients presenting with pyonecrotic complications of diabetic foot syndrome. The obtained findings suggest an unfavourable course of the wound process and increased risk of high amputations in the presence of lower limb critical ischaemia.