Effect of indomethacin on cerebral blood flow and development of oxygen convulsions.

Hyperbaric oxygenation modulates cerebral blood flow affecting the development of oxygen convulsions. Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po(2) increased. In rats receiving cyclooxygenase inhibitor indomethacin no convulsions were observed, blood flow and Po(2)were lower than in controls.

Brain blood flow modulates the neurotoxic action of hyperbaric oxygen via neuronal and endothelial nitric oxide.

Studies on conscious rats with inhibition of NO synthase were used to assess the dynamics of brain blood flow and EEG traces during hyperbaric oxygenation at 4 or 5 atm. Oxygen at a pressure of 4 atm induced cerebral vasoconstriction in intact animals and decreased blood flow by 11-18% (p < 0.05) during 60-min exposure to hyperbaric oxygenation.

[Mannitol application in surgical treatment of the abdominal aorta aneurysm].

During the operation performance for the abdominal aorta aneurysm after infusion of mannitol at 1.3 ml/kg dosage before aortal clumping the blood circulation was better than in control group, witnessed by bigger value of glomerular filtration by 20.8%, cardiac output--by 12%, lowering of total peripheric resistance of vessels--by 11%.

[Cerebral blood flow modulates hyperbaric oxygen induced neurotoxicity by neuronal and endothelial nitric oxide].

The goal of work was to reveal changes in microcirculation of the rat brain and the role of nitric oxide (NO) in development of seizures at hyperbaric oxygen exposure. The Wistar rats with implanted paired platinum electrodes in left and right striatum were used for experiments. The latency of seizures was defined by the EEG, the cerebral blood flow (CBF) was measured by hydrogen clearance.

[Cerebral blood flow dynamics in monkeys breathing a helium-oxygen mixture under high pressure].

Breathing with normoxic helium-oxygen mixture under high pressure successively induced tremor, myoclonia, seizures. Blood flow and the pO2 during the motor disorders increased, depending in the pressure, in the cortex, caudate nucleus, black substance and reticular formation.