Publications by authors named "O I Petrenko"
Human mesenchymal stromal cells (MSCs) are attractive for both medical practice and biomedical research. Nonfreezing short-term storage may provide safe and simple transportation and promote the practical use of MSCs. We aimed to determine the duration of efficient storage at ambient temperature (22°C) of human dermal MSCs in different three-dimensional organization and to investigate the role of cell metabolic mode in the resistance to the ambient storage damaging factors.
View Article and Find Full Text PDFBackground: Portal hypertension (PH) resulting from static and dynamic intrahepatic changes drives liver-related complications even after removing the underlying aetiological factor.
Objective: We investigated the impact of inflammation on the dynamic component of PH during disease regression in animal models of toxin-induced cirrhosis and patients with alcohol-related cirrhosis.
Methods: In mice, cirrhosis was induced via toxin application for 12 weeks followed by toxin-withdrawal allowing for one or 2 weeks of regression.
Article Synopsis
- The study focused on identifying unique metabolomic signatures in patients with porto-sinusoidal vascular disorder (PSVD) and cirrhosis to improve diagnosis.
- Serum samples from healthy volunteers and patients with PSVD or cirrhosis were analyzed using advanced techniques like liquid chromatography-mass spectrometry, identifying significant metabolic changes linked to PSVD.
- Machine learning models were developed to distinguish PSVD from cirrhosis and healthy controls; key metabolites like taurocholic acid showed strong potential for non-invasive diagnostic use.
Article Synopsis
- Cirrhosis creates a proinflammatory environment, and the study aims to analyze specific inflammation patterns across various causes of compensated cirrhosis in both animal models and human patients.
- In rat models, inflammation differed based on the cirrhosis cause, with choline-deficient high-fat diet rats showing the highest proinflammatory gene expression, while in humans, different liver diseases exhibited varying levels of inflammatory markers.
- Despite common upregulation of proinflammatory pathways in all types of liver disease, the impact on fibrosis and portal hypertension varied based on the specific etiology of the disease.
The war in Ukraine has exposed children to extremely high levels of acute and chronic stressors, which can impact their eating behaviour (EB). We aimed to determine the prevalence of war-induced, stress-related disruptions in EB of Ukrainian children. We conducted a cross-sectional online survey among parents of 5- to 17-year-old children, who had experienced the war in Ukraine in February-May 2023.
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