Synthesis, crystal structure and Hirshfeld surface analysis of (3)-4-[(4-amino-1,2,5-oxa-diazol-3-yl)amino]-3-bromo-1,1,1-tri-fluoro-but-3-en-2-one.

In the title compound, CHBrFNO, the oxa-diazole ring is essentially planar with a maximum deviation of 0.003 (2) Å. In the crystal, mol-ecular pairs are connected by N-H⋯N hydrogen bonds, forming dimers with an (8) motif.

[Allergic rhinitis in the pregnant women].

The objective of the present work was to elucidate the specific features of the clinical picture of allergic rhinitis in the pregnant women. The study included 156 pregnant women presenting with the persisting form of the disease and 63 patients having its intermitting form. The character of the endoscopic manifestations of rhinitis, chronic tonsillitis, and gastroesophageal reflux was evaluated with the use of a scoring system.

[Differential diagnostics of the causes responsible for a cough in the pregnant women].

The objective of the present study was to elucidate the causes responsible for a cough in the pregnant women. It involved 92 patients including 23 ones presenting with bronchial asthma and 69 having no manifestations of asthma in their medical histories but suffering from dry cough that started after the beginning of pregnancy. All the patients were given counseling by the otorhinolaryngology and pulmonology specialists.

[The HRM-new molecular technique of detection of pharmaceutical resistance of micobacteria of tuberculosis].

The early detection of isolates of mycobacterium of tuberculosis resistant to anti-tuberculosis pharmaceuticals is ultimately needed for optimization of treatment scheme and prevention of propagation of resistant strains. The literature review presents analysis of data concerning the new, fast and inexpensive technique of detection of mutations in genes of mycobacterium of tuberculosis competent for multiple medicinal resistance. The molecular genetic technique HRM (high resolution melting curve analysis) is based on implementation of amplification of DNA fragments with subsequent analysis of their curves of melting with high resolution.

[Placenta of normal women and of patients with bronchial asthma of various degrees of severity (immunohistochemical and histological study)].

The aim of the study was to examine the immunomorphological features and expression of immunohistochemical markers that indicate the presence of immune inflammation in the placenta in normal pregnancy and in pregnancy complicated by bronchial asthma (BA) of varying degrees of severity. The of 80 samples of placenta from patients with BA were studied immunohistochemically and histologically to demonstrate the fixation of C3 fraction of complement, fibrinogen, IL-4, IL-6, IgA, IgM, IgG, and the expression of CD31, CD35, CD57 and CD83 molecules. The largest number of immune deposits fixed in the placenta and damaging the structures of the placental barrier (vascular endothelium and syncytiotrophoblast membranes) was found in women with moderate to severe BA.