[Rapid determination of cephalexin in biological media].

The behavior of cephalexin in pharmaceutical and biological media was studied by spectrophotometric method. The ranges of linearity and the limits of cephalexin detection were determined. The possibilities of spectrophotometric cephalexin determination in mixed saliva and in blood serum were shown.

[Study on pharmacokinetics of cefuroxime by dynamics of its distribution in oral fluid of patients with sinusitis].

A method for quantitative determination of cefuroxime in mixed saliva of patients with sinusitis by using spectrophotometer Shimadzu UV-1800, combined with the IBM PC is described. The conditions of the determination were the following: λ = 266 nm, a quartz cuvette, the analysis time of 10 minutes. The method for determination of cefuroxime is characterized by high specificity, accuracy, use of small amounts of oral fluid and expressivity.

[Rapid determination of ceftriaxone in mixed saliva of practically healthy subjects and patients with infectious and somatic pathologies].

A method for spectroscopic determination of ceftriaxone in saliva of healthy subjects and patients with upper respiratory tract infections was developed. The concentration range is 1-50 mcg/ml. The method is express and simple, and can be used to determine ceftriaxone in clinical tests and pharmacokinetic studies.

[Evaluation of the course of an infectious process by erythrocyte membrane permeability].

The physical and chemical parameters of red blood cells were studied in patients with urinary tract infection. The permeability parameters were proposed to study erythrocyte membrane permeability. Complete recovery of the latter in patients with somatic diseases due to antibacterial therapy was found to suggest that the preservation of erythrocyte dysfunction.

[Spectrophotometric determination of cefazolin in mixed saliva of practically healthy subjects and patients with infective somatic pathology].

The behaviour of cefazolin in aqueous and biological media with varying the antibiotic concentration was studied by UV-spectroscopy. Range of the contents and the detection limits of cefazolin were determined. The procedure of UV-spectroscopy of cefazolin in mixed saliva of patients with urinary tract infection was developed.