[About connection of clinical manifestations of glomerulonephritis with features of the thyroid status of patients].

Background: There are four clinical variants of glomerulonephritis (GN) - urinary (latent), hypertensive, nephrotic and mixed. It was found that the features of clinical manifestations of GN that determine its clinical variant do not depend on the etiology, pathogenesis and morphological form of the disease. Taking into account the obtained data on the association of nephrotic syndrome with hypofunction of the thyroid gland, we suggested, that the formation of clinical variants of GN may be influenced by the features of the thyroid status of patients.

The role of circulating cytokines and thyroid hormones in the development of the nephrotic variant of glomerulonephritis.

Unlabelled: The purpose of the research - studying the features of the production of pro- and anti-inflammatory cytokines, as well as indicators of thyroid status in patients with nephrotic variant of glomerulonephritis (GN). Research methods.

Methods: The examination involved 78 patients with primary GN, including 30 patients with nephrotic syndrome (NS) and 48 GN patients who had no NS symptoms.

[THE CHARACTERISTICS OF CYTOKINE STATUS UNDER DIFFERENT CLINICAL VARIANTS OF GLOMERULONEPHRITIS].

The article presents results of identification of indicators of cytokine status in 58 patients with glomerulonephritis using solid-phase immunoenzyme analysis. It is established that in patients with glomerulonephritis the level of pro-inflammatory and anti-inflammatory cytokines (IL-lβ, IL-2, IL-10 and Ra-IL-1β) circulating in blood is augmented. The differences are established concerning cytokine status of patients depending on clinical type of disease.