Publications by authors named "O Horvath"
Mitochondria form a dynamic network in cells, regulated by the balance between mitochondrial fusion and fission. The inhibition of mitochondrial fission can have positive effects in acute ischemic/reperfusion injury models by preventing the fall in mitochondrial membrane potential associated with fission processes. However, inhibition of fission in chronic models is disadvantageous because it obstructs the elimination of damaged mitochondrial fragments.
View Article and Find Full Text PDFDue to its rarity, it takes months for patients to be correctly diagnosed with pemphigus vulgaris. This delay can be exacerbated by factors such as incorrect biopsy site selection. When the epidermis detaches from the dermis, evaluating fluorescence patterns is impossible.
View Article and Find Full Text PDFArticle Synopsis
- Super-resolution microscopy provides high-detail imaging but faces challenges with thick biological specimens, such as oocytes.
- Optimizing sample preparation is crucial for achieving optical clarity, which enhances imaging capabilities for larger structures.
- This study introduces a new method involving alcohol dehydration and high-refractive-index mounting, allowing for successful 3D imaging of mouse oocytes, thereby improving the analysis of complex biological processes.
Article Synopsis
- Trichophyton soudanense, Trichophyton violaceum, and Trichophyton tonsurans are uncommon fungal pathogens in Germany primarily affecting travelers to tropical areas, prompting a study in Munich to analyze their clinical significance.
- A retrospective analysis over nearly a decade involved over 87,000 swabs, finding that 2.1% were positive for these fungi, with T. tonsurans being the most prevalent, especially in young patients.
- The findings highlight the importance of considering these rare infections, particularly Tinea capitis, in patients with relevant travel histories and potential exposure through social contact.
Background: The aim was to elaborate a predictive model to find responders for the corticosteroid switch (from prednisolone to dexamethasone) at the first prostate-specific antigen (PSA) progression (≥25% increase) during abiraterone acetate (AA) treatment of metastatic castration-resistant prostate cancer (mCRPC) patients.
Methods: If PSA has decreased (≥25%) after switch, patients were considered responders. Logistic regression of 19 dichotomized parameters from routine laboratory and patients' history was used to find the best model in a cohort of 67 patients.