Publications by authors named "O Horakova"
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) plays a crucial role in regulation of metabolic homeostasis. To understand the role of the catalytic α2 subunit of AMPK in skeletal muscle energy metabolism, myotube cultures were established from and mice. Myotubes from mice had lower basal oleic acid and glucose oxidation compared to myotubes from mice.
View Article and Find Full Text PDFPostnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice.
Am J Physiol Endocrinol Metab
December 2024
Article Synopsis
- The study investigates how a temporary increase in leptin levels after birth, known as leptin surge, may influence future obesity risk in mice, particularly those genetically prone or resistant to obesity.
- The research specifically examines the sources of leptin during this surge and how factors like sex and genetics affect its role in weight gain when placed on different diets.
- Findings reveal that leptin levels at 2 weeks old can predict adult body weight and fat levels, highlighting the importance of early leptin exposure in determining obesity outcomes later in life.
Metabolic dysfunction-associated steatotic liver disease (MASLD) occurs in subjects with obesity and metabolic syndrome. MASLD may progress from simple steatosis (i.e.
View Article and Find Full Text PDFArticle Synopsis
- Obesity can harm bones and fat handling in both mice and people.
- Omega-3 fatty acids may help improve how the body manages sugar and supports healthy bones in those with obesity.
- A study found that mice on a high-fat diet supplemented with omega-3s had better bone health and less fat in their bones compared to those only on the high-fat diet.
Introduction: Non-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice. Due to possible differences in steatohepatitis development between different C57BL/6 substrains, we examined how thermoneutrality affects NAFLD progression in C57BL/6N mice.
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