Publications by authors named "O Hiraoka"
Unlabelled: Ribavirin (RBV) is often used in conjunction with interferon-based therapy for patients with chronic hepatitis C. There is a drastic difference in the anti-hepatitis C virus (HCV) activity of RBV between the HuH-7-derived assay system, OR6, possessing the RBV-resistant phenotype (50% effective concentration [EC50 ]: >100 µM) and the recently discovered Li23-derived assay system, ORL8, possessing the RBV-sensitive phenotype (EC50 : 8 µM; clinically achievable concentration). This is because the anti-HCV activity of RBV was mediated by the inhibition of inosine monophosphate dehydrogenase in RBV-sensitive ORL8 cells harboring HCV RNA.
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- Artemisinin is crucial for treating malaria caused by the deadly Plasmodium falciparum, but resistance is emerging, prompting the search for new treatments.
- Researchers found that synthetic endoperoxides N-89 and N-251 showed strong antimalarial effects in lab tests.
- The study identifies PfERC, a protein associated with endoperoxides, as a potential target for new antimalarial drugs, which could help tackle resistance issues.
Malaria is one of the world's deadliest diseases and is becoming an increasingly serious problem as malaria parasites develop resistance to most of the antimalarial drugs used today. We previously reported the in vitro and in vivo antimalarial potencies of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) and 6-(1,2,6,7-tetraoxaspiro[7.
View Article and Find Full Text PDFPlasmodium falciparum, the major causative parasite for the disease, has acquired resistance to most of the antimalarial drugs used today, presenting an immediate need for new antimalarial drugs. Here, we report the in vitro and in vivo antimalarial activities of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against P.
View Article and Find Full Text PDFMolecular mechanisms in two cell death-types, necrosis and apoptosis, induced by 5-fluoro-2'-deoxyuridine.
Nucleic Acids Symp Ser (Oxf)
November 2010
Article Synopsis
- A study finds that the anticancer drug 5-fluoro-2'-deoxyuridine (FUdR) induces different types of cell death in mouse cancer cells: necrosis in F28-7 cells and apoptosis in variant F28-7-A cells.
- Researchers used transcriptomic and proteomic analyses to investigate the differences in gene and protein expression related to cell death types, identifying lamin B1 as a key protein associated with necrosis in F28-7 cells.
- Knocking down lamin B1 expression in F28-7 cells changed their death response from necrosis to apoptosis, highlighting its potential role in regulating cell death morphology.