A One-Pot Synthesis of N-Aryl-2-Oxazolidinones and Cyclic Urethanes by the Lewis Base Catalyzed Fixation of Carbon Dioxide into Anilines and Bromoalkanes.

The multicomponent assembly of pharmaceutically relevant N-aryl-oxazolidinones through the direct insertion of carbon dioxide into readily available anilines and dibromoalkanes is described. The addition of catalytic amounts of an organosuperbase such as Barton's base enables this transformation to proceed with high yields and exquisite substrate functional-group tolerance under ambient CO2 pressure and mild temperature. This report also provides the first proof-of-principle for the single-operation synthesis of elusive seven-membered ring cyclic urethanes.

Peroperative difficulties in fluoroscopy of the femoral head in massive obese patient: enhanced visualization by intra-articular contrast agent.

Peroperative fluoroscopic visualization of the femoral head in massive obese patient can be enhanced by the administration of intra-articular contrast agent into the hip joint. It provides safe alternative for compromised resolution during the introduction of femoral head screws. We report our experiences with one patient as a technical report and believe that in certain cases this method may be quite helpful.

The effect of clozapine on the course of illness in chronic schizophrenia: focus on treatment outcome in out-patients.

Forty-eight consecutive schizophrenic patients treated with clozapine (mean daily dose 436 mg) for at least 1 year (mean 7.6, range 2.2-14.

Comparison of a new immunoturbidometric assay of human serum lipoprotein (a) to the ELISA and the IRMA methods.

In the present work we have tested a new immunoturbidometric (IT) lipoprotein(a) (Lp(a)) assay and compared it with two other Lp(a) assay systems (IRMA and ELISA) commonly used in clinical chemistry laboratories. In addition, we have examined the effects of long-term storage and plasminogen on the results of Lp(a). Intra-assay and inter-assay coefficients of variation of the IT method were from 1.