Publications by authors named "O Havndrup"
Background: Imaging-guided percutaneous coronary intervention (PCI) is associated with better clinical outcomes than angiography-guided PCI. Whether routine optical coherence tomography (OCT) guidance in PCI of lesions involving coronary-artery branch points (bifurcations) improves clinical outcomes as compared with angiographic guidance is uncertain.
Methods: We conducted a multicenter, randomized, open-label trial at 38 centers in Europe.
Article Synopsis
- Chronic total occlusions (CTO) are common in patients with coronary artery disease, and while percutaneous coronary intervention (PCI) is a viable treatment, more randomized studies are needed to compare its effectiveness against optimal medical therapy (OMT) alone.
- This trial assesses the impact of CTO-PCI on patients with myocardial ischemia and determines effects on quality of life and major adverse cardiac and cerebral events (MACCE) through a randomized approach following an initial period of OMT.
- The results will provide insights that could influence future guidelines on the treatment of chronic total occlusions, depending on whether CTO-PCI shows significant benefits.
Article Synopsis
- Approximately half of young patients with atrioventricular block (AVB) don’t have a known cause; this study looked into potential genetic factors in these cases.
- Researchers analyzed data from a Danish registry to find patients under 50 who received a pacemaker for AVB, and invited 226 out of 471 identified patients for genetic screening.
- They found genetic variants linked to AVB in 12 patients (5%), with most variants related to family history of AVB or sudden cardiac death, indicating the importance of genetic testing for diagnosis and risk assessment.
Background: In patients suspected of acute coronary syndrome, but where the coronary angiography (CAG) has shown unobstructed coronary arteries differential diagnoses include spontaneous coronary artery dissection and takotsubo cardiomyopathy. This case report presents a patient with spontaneous coronary artery dissection but diagnostic signs suspicious of takotsubo cardiomyopathy. Which leads to a consideration of the co-existence of the diseases.
View Article and Find Full Text PDFEvolutionary dissection of mtDNA hg H: a susceptibility factor for hypertrophic cardiomyopathy.
Mitochondrial DNA A DNA Mapp Seq Anal
August 2020
Article Synopsis
- Mitochondrial DNA haplogroup H is linked to a higher risk of hypertrophic cardiomyopathy (HCM), though specific SNPs associated with this risk have not been identified.
- A study compared the distribution of H haplogroup subtypes in 55 HCM patients with two control groups from Denmark and found a higher proportion of the H3 subtype in the HCM group.
- The distinct proportions of H subhaplogroups suggest a difference between HCM cases and controls, although the significance of these differences remains unclear without further functional studies.