Publications by authors named "O H Wong"
Efficient methods and universal DNA elements are eagerly required for the expression of proteins and the production of target chemicals in synthetic biology and metabolic engineering. This paper develops a customized-design approach by utilizing the host-independent T7 expression system (HITES), which facilitates the rational design and rapid construction of T7 expression systems. Firstly, the EL (Upper-limit value of initial enzyme activity) value is discovered to play a pivotal factor in the successful construction of the T7 expression system, different host strains exhibit varying EL values, and this study presents a method to measure the EL values.
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- This study investigated the use of MR-guided radiotherapy (MRgRT) for prostate cancer patients who had undergone surgery, focusing on its clinical outcomes and patient tolerability.
- A total of 30 patients received adaptive MRgRT and were monitored for progression-free survival (PFS) and adverse events over an average follow-up period of around 32 months.
- The results indicated high PFS rates (96.4% at 2 years, 78.8% at 3 years) and low rates of significant side effects, suggesting MRgRT is effective and well-tolerated in this patient group.
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- The study investigates differences in sleep architecture among children with narcolepsy, idiopathic hypersomnia (IH), and those who are subjectively sleepy, aiming to improve diagnostic methods.
- It involved 28 children with narcolepsy, 11 with IH, and 26 control subjects, analyzing sleep stability and disturbance through polysomnography and multiple sleep latency tests (MSLT).
- Results showed narcoleptic children had more frequent wake transitions and shorter REM episode durations compared to the other groups, suggesting that specific sleep patterns could help differentiate between these sleep disorders in children.
Accumulating evidence suggests that gut microbiota alterations influence brain function and could serve as diagnostic biomarkers and therapeutic targets. The potential of using fecal microbiota signatures to aid autism spectrum disorder (ASD) detection is still not fully explored. Here, we assessed the potential of different levels of microbial markers (taxonomy and genome) in distinguishing children with ASD from age and gender-matched typically developing peers ( = 598, ASD vs TD = 273 vs 325).
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