Impact of vaginal ascorbic acid on abnormal vaginal microflora.

Purpose: To evaluate the impact of vaginal ascorbic acid (vitamin C) as a treatment/maintenance regimen on increased vaginal pH and abnormal microflora on wet mounts in premenopausal women.

Methods: A randomized study of 140 asymptomatic, low-risk pregnant and non-pregnant premenopausal women with vaginal pH ≥ 4.5 and a variety of partly/completely disrupted Lactobacillus microflora patterns on wet mounts in five outpatient clinics was carried out.

Factors related to elevated vaginal pH in the first trimester of pregnancy.

Objective: To assess different bacterial and epidemiological factors associations with increased vaginal pH in the pregnant women population during the first trimester.

Design: A cross-sectional, observational study.

Setting: Three outpatient clinics in Riga.

[Alkylating derivatives of 2-amino-2-deoxysugars and 1-methylamino-1-deoxypolyols (synthesis and experimental study)].

A number of derivatives of 2-amino-2-deoxysaccharides and 1-methylamino-1-deoxypolyols acylated by cytotoxic phenylalkanic and amino acids were synthesized and experimentally tested for antitumor activity. Some compounds showed a high antitumor activity against plasmacytoma MOPC-406: a 2-fold increase in experimental animals survival and a 80--100% cure rate were observed. Physicochemical properties, particularly, stability in aqueous solution and antitumor activity of one of the most potent compounds--1-methylamino-1-deoxy-1-N[p-di(2-chloroethyl) aminophenylacetyl]-D-glucitol (Agluphen)--are described in detail.

[Alkylating derivatives of 2-amino-2-desoxy-1,3,4,6-tetraacetyl-D-glucopyranose (synthesis and experimental study)].

The writers report the results of synthesis and experimental studies of 2-amino-2-desoxy-1, 3, 4, 6-tetraacetyl-D-glucopyranose derivatives acylated by n-di-/2-chloroethyl/aminophenyl acetic acid (chlorophenacyl), n-di-/2-chloroethyl/aminophenyl-N-acetyl-DL-alanine (acetylsarcolysin) and n-di-/2-chloroethyl/aminophenyl-N-acetyl-DL-alanyl-DL-valine (acetylsarcolysin valine). Studies on the antitumor activity were carried out on mice with 8 different transplantable tumors. The addition of glucosamine to alkylating substances containing biologically active components was found to change their properties.